Department of Biological Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90128 Palermo, Italy.
Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), 90015 Cefalù, Italy.
Genes (Basel). 2023 May 6;14(5):1046. doi: 10.3390/genes14051046.
During embryonic development, stem cells undergo the differentiation process so that they can specialize for different functions within the organism. Complex programs of gene transcription are crucial for this process to happen. Epigenetic modifications and the architecture of chromatin in the nucleus, through the formation of specific regions of active as well as inactive chromatin, allow the coordinated regulation of the genes for each cell fate. In this mini-review, we discuss the current knowledge regarding the regulation of three-dimensional chromatin structure during neuronal differentiation. We also focus on the role the nuclear lamina plays in neurogenesis to ensure the tethering of the chromatin to the nuclear envelope.
在胚胎发育过程中，干细胞经历分化过程，以便能够在生物体中专门执行不同的功能。转录基因的复杂程序对于这个过程的发生至关重要。核内染色质的表观遗传修饰和结构通过形成活跃和非活跃染色质的特定区域，允许对每个细胞命运的基因进行协调调节。在这个小型综述中，我们讨论了关于神经元分化过程中三维染色质结构调节的最新知识。我们还专注于核纤层在神经发生中的作用，以确保染色质与核膜的连接。
