Program in Aging Sciences, Universidade São Judas Tadeu (USJT), São Paulo 03166-000, SP, Brazil.
Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Int J Environ Res Public Health. 2023 May 20;20(10):5891. doi: 10.3390/ijerph20105891.
To evaluate the effect of whey protein (WP) supplementation associated with resistance training (RT) on glycemic control, functional tasks, muscle strength, and body composition in older adults living with type 2 diabetes mellitus (T2DM). Secondly, to evaluate the safety of the protocol for renal function.
The population comprised twenty-six older men living with T2DM (68.5 ± 11.5 years old). The participants were randomly assigned to the Protein Group (PG) and the Control Group (CG). The handgrip test and evolution of exercise loads, according to the Omni Resistance Exercise Scale, evaluated muscle strength. Functional tasks were assessed by force platform in three different protocols: Sit-to-Stand, Step/Quick Turn, and Step Up/Over. Body composition was evaluated by bioimpedance and glycemic control and renal function were assessed by biochemical analyses. Both groups performed RT for 12 weeks, twice a week, prioritizing large muscle groups. Protein supplementation was 20 g of whey protein isolate and the CG was supplemented with an isocaloric drink, containing 20 g of maltodextrin.
There was a significant difference in muscle strength, according to the evolution of the exercise loads, but it was not confirmed in the handgrip test. However, there was no significant difference between the groups, regarding performance in functional tasks, glycemic control, or body composition. Renal function showed no alteration.
The intake of 20 g of WP in older male adults living with T2DM did not increase the effect of RT on muscle strength, functional tasks, and glycemic control. The intervention was proven safe regarding renal function.
评估乳清蛋白（WP）补充联合抗阻训练（RT）对 2 型糖尿病（T2DM）老年患者血糖控制、功能任务、肌肉力量和身体成分的影响。其次，评估该方案对肾功能安全性。
研究人群包括 26 名患有 T2DM 的老年男性（68.5±11.5 岁）。参与者随机分配到蛋白质组（PG）和对照组（CG）。握力测试和根据 Omni 抗阻运动量表进行的运动负荷演变评估肌肉力量。通过三个不同的方案（坐站、跨步/快速转身、跨步上/越过）在力台上评估功能任务。身体成分通过生物阻抗评估，血糖控制和肾功能通过生化分析评估。两组均进行为期 12 周、每周 2 次的 RT，优先考虑大肌肉群。蛋白质补充为 20 克乳清蛋白分离物，CG 补充等热量饮料，含 20 克麦芽糊精。
根据运动负荷的演变，肌肉力量有显著差异，但握力测试未得到证实。然而，两组在功能任务、血糖控制或身体成分方面的表现没有差异。肾功能没有改变。
在患有 T2DM 的老年男性中摄入 20 克 WP 并未增加 RT 对肌肉力量、功能任务和血糖控制的影响。该干预对肾功能是安全的。
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