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罗马尼亚首例经组织病理学诊断为肝假瘤的人类肝片吸虫病病例报告

The First Case of Human Hepatic Fasciolosis Presented as Hepatic Pseudotumor Histopathologically Diagnosed in Romania-A Case Report.

作者信息

Birlutiu Victoria, Birlutiu Rares-Mircea

机构信息

County Clinical Emergency Hospital Sibiu-Infectious Diseases Clinic, Faculty of Medicine Sibiu, Lucian Blaga University of Sibiu, Strada Lucian Blaga, Nr. 2A, 550169 Sibiu, Romania.

Clinical Hospital of Orthopedics, Traumatology, and Osteoarticular TB "Foisor" Bucharest, B-dul Ferdinand 35-37, Sector 2, 021382 Bucharest, Romania.

出版信息

Healthcare (Basel). 2023 May 17;11(10):1451. doi: 10.3390/healthcare11101451.

Abstract

Human hepatic fasciolosis has been reported in 81 countries, some of which are endemic areas. In Europe, case reports from humans were published in Portugal, Spain, France, and Italy. Regarding Romania, we do not have any data on the prevalence of this parasitosis, with the exception of two cases of twins that were born in Romania and diagnosed in the last 37 years in Italy after joining their mother that lived there. We report the case of a patient diagnosed in Romania with chronic fasciolosis, presented as a hepatic pseudotumor that was diagnosed during the histopathological examination of the hepatic lesion. The patient received oral treatment with triclabendazole, two doses of 10 milligrams (mg) per kilogram (kg) of body weight, given 12 h apart, with no side effects during or after the treatment. The evolution of the patient was favorable. In conclusion, even in areas free of human fasciolosis, the presence of an anemic syndrome especially in children, abdominal pain in the upper quadrants, associated or not with other digestive manifestations, even more so associated with eosinophilia in the acute phase, should be carefully evaluated for ruling out a parasitosis such as fasciolosis even in countries where this diagnosis seems unlikely.

摘要

已有81个国家报告了人类肝片吸虫病,其中一些是流行地区。在欧洲,葡萄牙、西班牙、法国和意大利发表了人类病例报告。关于罗马尼亚,除了在罗马尼亚出生、37年后随居住在意大利的母亲前往意大利后被诊断出的一对双胞胎病例外,我们没有关于这种寄生虫病流行情况的任何数据。我们报告了一例在罗马尼亚被诊断为慢性肝片吸虫病的患者,表现为肝部假瘤,在对肝脏病变进行组织病理学检查时被诊断出来。该患者接受了三氯苯达唑口服治疗,每公斤体重服用两剂,每剂10毫克,间隔12小时服用,治疗期间及治疗后均无副作用。患者病情好转。总之,即使在没有人类肝片吸虫病的地区,对于出现贫血综合征(尤其是儿童)、上腹部腹痛(无论是否伴有其他消化系统表现),特别是在急性期伴有嗜酸性粒细胞增多的情况,即使在似乎不太可能做出这种诊断的国家,也应仔细评估以排除肝片吸虫病等寄生虫病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75c9/10218619/0e2d12c5ee85/healthcare-11-01451-g001.jpg

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