Fengler R, Pankrath K, Baumgarten E, Beck C, Becker H, Buchmann S, Grosch-Wörner I, Nessler G, Schuppert W, Henze G
Klin Padiatr. 1986 May-Jun;198(3):245-9. doi: 10.1055/s-2008-1026884.
Case histories of two infants with malignant melanoma are presented. Both tumors had developed from a congenital mole to advanced disease with lymph node metastasis at time of diagnosis, findings which are commonly correlated with poor outcome. Initially, both patients were surgically treated. From the experience with few described cases of melanoma in childhood and with a large number of adult patients, neither chemotherapy and conventional BCG immunotherapy nor irradiation seem to be an effective treatment and are accompanied by many adverse side effects. Therefore in one patient therapy was limited to surgery alone. In the other child it was followed by treatment with high-dose recombinant alpha-2-interferon (1 Mill. i.u./Kg X d) plus an H2-receptor antagonist. Unexpectedly this girl developed neurological side effects, characterized by spastic paraparesis, indicating damage to the first motoneuron. All symptoms completely resolved after discontinuation of drugs within three months. Both children have been in complete remission for 18+ and 32+ months, respectively.
本文介绍了两名患有恶性黑色素瘤的婴儿的病例史。两种肿瘤均由先天性痣发展而来，诊断时已发展为晚期疾病并伴有淋巴结转移，这些发现通常与不良预后相关。最初，两名患者均接受了手术治疗。从少数已描述的儿童黑色素瘤病例以及大量成年患者的经验来看，化疗、传统卡介苗免疫疗法和放疗似乎都不是有效的治疗方法，并且伴有许多不良副作用。因此，一名患者仅接受了手术治疗。另一名儿童在手术后接受了高剂量重组α-2-干扰素（100万国际单位/千克×天）加H2受体拮抗剂的治疗。出乎意料的是，这个女孩出现了神经方面的副作用，表现为痉挛性截瘫，提示第一运动神经元受损。停药后三个月内所有症状完全消失。两名儿童分别已完全缓解18个多月和32个多月。
