Laboratory of Tumor Cell Biology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo 1088639, Japan.
Int J Mol Sci. 2023 May 13;24(10):8731. doi: 10.3390/ijms24108731.
CD30, a member of the tumor necrosis factor receptor superfamily, plays roles in pro-survival signal induction and cell proliferation in peripheral T-cell lymphoma (PTCL) and adult T-cell leukemia/lymphoma (ATL). Previous studies have identified the functional roles of CD30 in CD30-expressing malignant lymphomas, not only PTCL and ATL, but also Hodgkin lymphoma (HL), anaplastic large cell lymphoma (ALCL), and a portion of diffuse large B-cell lymphoma (DLBCL). CD30 expression is often observed in virus-infected cells such as human T-cell leukemia virus type 1 (HTLV-1). HTLV-1 is capable of immortalizing lymphocytes and producing malignancy. Some ATL cases caused by HTLV-1 infection overexpress CD30. However, the molecular mechanism-based relationship between CD30 expression and HTLV-1 infection or ATL progression is unclear. Recent findings have revealed super-enhancer-mediated overexpression at the CD30 locus, CD30 signaling via trogocytosis, and CD30 signaling-induced lymphomagenesis in vivo. Successful anti-CD30 antibody-drug conjugate (ADC) therapy for HL, ALCL, and PTCL supports the biological significance of CD30 in these lymphomas. In this review, we discuss the roles of CD30 overexpression and its functions during ATL progression.
CD30 是肿瘤坏死因子受体超家族的一员，在周围 T 细胞淋巴瘤（PTCL）和成人 T 细胞白血病/淋巴瘤（ATL）中发挥促生存信号诱导和细胞增殖的作用。先前的研究已经确定了 CD30 在表达 CD30 的恶性淋巴瘤中的功能作用，不仅在 PTCL 和 ATL 中，而且在霍奇金淋巴瘤（HL）、间变性大细胞淋巴瘤（ALCL）和部分弥漫性大 B 细胞淋巴瘤（DLBCL）中也是如此。CD30 表达通常在人类 T 细胞白血病病毒 1（HTLV-1）等病毒感染的细胞中观察到。HTLV-1 能够使淋巴细胞永生化并产生恶性肿瘤。一些由 HTLV-1 感染引起的 ATL 病例过度表达 CD30。然而，CD30 表达与 HTLV-1 感染或 ATL 进展之间基于分子机制的关系尚不清楚。最近的发现揭示了 CD30 基因座的超增强子介导的过表达、通过 trogocytosis 的 CD30 信号传导以及 CD30 信号诱导的体内淋巴瘤发生。针对 HL、ALCL 和 PTCL 的成功抗 CD30 抗体药物偶联物（ADC）治疗支持了 CD30 在这些淋巴瘤中的生物学意义。在这篇综述中，我们讨论了 CD30 过表达及其在 ATL 进展过程中的作用。
