Cavero-Redondo Iván, Saz-Lara Alicia, Martínez-García Irene, Bizzozero-Peroni Bruno, Díaz-Goñi Valentina, Díez-Fernández Ana, Moreno-Herráiz Nerea, Pascual-Morena Carlos
Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca 3460000, Chile.
Health and Social Research Centre, Universidad de Castilla-La Mancha, 16001 Cuenca, Spain.
J Clin Med. 2023 May 18;12(10):3535. doi: 10.3390/jcm12103535.
(1) Background: Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for approximately 50% of all patients with HF. In the absence of pharmacological treatments that have been successful in reducing mortality or morbidity in this pathology, physical exercise is recognized as an important adjunct in the treatment of HF. Therefore, the objective of this study is to compare the efficacy of combined training and high intensity interval training (HIIT) on exercise capacity, diastolic function, endothelial function, and arterial stiffness in participants with HFpEF. (2) Methods: The ExIC-FEp study will be a single-blind, 3-arm, randomized clinical trial (RCT) conducted at the Health and Social Research Center of the University of Castilla-La Mancha. Participants with HFpEF will be randomly assigned (1:1:1) to the combined exercise, HIIT or control group to evaluate the efficacy of physical exercise programs on exercise capacity, diastolic function, endothelial function, and arterial stiffness. All participants will be examined at baseline, at three months and at six months. (3) Results: The findings of this study will be published in a peer-reviewed journal. (4) Conclusions: This RCT will represent a significant advance in the available scientific evidence on the efficacy of physical exercise in the treatment of HFpEF.
(1) 背景：射血分数保留的心力衰竭（HFpEF）约占所有心力衰竭患者的50%。鉴于目前尚无成功降低该病症死亡率或发病率的药物治疗方法，体育锻炼被视为心力衰竭治疗的重要辅助手段。因此，本研究的目的是比较联合训练和高强度间歇训练（HIIT）对HFpEF参与者运动能力、舒张功能、内皮功能和动脉僵硬度的疗效。(2) 方法：ExIC-FEp研究将是一项在卡斯蒂利亚-拉曼恰大学健康与社会研究中心进行的单盲、三臂随机临床试验（RCT）。HFpEF参与者将被随机分配（1:1:1）至联合运动组、HIIT组或对照组，以评估体育锻炼计划对运动能力、舒张功能、内皮功能和动脉僵硬度的疗效。所有参与者将在基线、三个月和六个月时接受检查。(3) 结果：本研究结果将发表在同行评审期刊上。(4) 结论：这项RCT将代表体育锻炼治疗HFpEF有效性的现有科学证据取得重大进展。
