Minici Roberto, Serra Raffaele, Maglia Claudio, Guzzardi Giuseppe, Spinetta Marco, Fontana Federico, Venturini Massimo, Laganà Domenico
Radiology Unit, Dulbecco University Hospital, 88100 Catanzaro, Italy.
Vascular Surgery Unit, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Dulbecco University Hospital, 88100 Catanzaro, Italy.
J Pers Med. 2023 May 11;13(5):812. doi: 10.3390/jpm13050812.
Hemostasis of the femoral arterial access site by manual compression or a vascular closure device is critical to the safe completion of any endovascular procedure. Previous investigations evaluated the hemostatic efficacy at the radial access site of some chitosan-based hemostatic pads. This study aims to assess the efficacy and safety of a new chitosan-based hemostatic dressing, namely Axiostat, in aiding manual compression closure of the femoral arterial access site in patients undergoing endovascular treatments. Furthermore, the outcomes were compared with evidence on manual compression alone and vascular closure devices.
This investigation is a two-center retrospective analysis of 120 consecutive patients who had undergone, from July 2022 to February 2023, manual compression closure of the femoral arterial access site aided by the Axiostat hemostatic dressing. Endovascular procedures performed with introducer sheaths ranging from 4 Fr to 8 Fr were evaluated.
Primary technical success was achieved in 110 (91.7%) patients, with adequate hemostasis obtained in all cases of prolonged manual compression requirements. The mean time-to-hemostasis and time-to-ambulation were 8.9 (±3.9) and 462 (±199) minutes, respectively. Clinical success was achieved in 113 (94.2%) patients, with bleeding-related complications noted in 7 (5.8%) patients.
Manual compression aided by the Axiostat hemostatic dressing is effective and safe in achieving hemostasis of the femoral arterial access site in patients undergoing endovascular treatment with a 4-8 Fr introducer sheath.
通过手动压迫或血管闭合装置实现股动脉穿刺部位的止血对于任何血管内手术的安全完成至关重要。先前的研究评估了一些基于壳聚糖的止血垫在桡动脉穿刺部位的止血效果。本研究旨在评估一种新型基于壳聚糖的止血敷料Axiostat在辅助接受血管内治疗的患者手动压迫闭合股动脉穿刺部位方面的有效性和安全性。此外，将结果与单纯手动压迫和血管闭合装置的证据进行了比较。
本研究是一项两中心回顾性分析，纳入了2022年7月至2023年2月期间连续120例接受Axiostat止血敷料辅助手动压迫闭合股动脉穿刺部位的患者。对使用4 Fr至8 Fr血管鞘进行的血管内手术进行了评估。
110例（91.7%）患者取得了主要技术成功，在所有需要延长手动压迫的病例中均实现了充分止血。平均止血时间和下床活动时间分别为8.9（±3.9）分钟和462（±199）分钟。113例（94.2%）患者取得了临床成功，7例（5.8%）患者出现了与出血相关的并发症。
在使用4-8 Fr血管鞘进行血管内治疗的患者中，Axiostat止血敷料辅助手动压迫在实现股动脉穿刺部位止血方面是有效且安全的。
