Cacaci Margherita, Biagiotti Giacomo, Toniolo Gianluca, Albino Martin, Sangregorio Claudio, Severi Mirko, Di Vito Maura, Squitieri Damiano, Contiero Luca, Paggi Marco, Marelli Marcello, Cicchi Stefano, Bugli Francesca, Richichi Barbara
Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Nanomaterials (Basel). 2023 May 9;13(10):1585. doi: 10.3390/nano13101585.
The increasing resistance of bacteria to conventional antibiotics represents a severe global emergency for human health. The broad-spectrum antibacterial activity of silver has been known for a long time, and silver at the nanoscale shows enhanced antibacterial activity. This has prompted research into the development of silver-based nanomaterials for applications in clinical settings. In this work, the synthesis of three different silver nanoparticles (AgNPs) hybrids using both organic and inorganic supports with intrinsic antibacterial properties is described. The tuning of the AgNPs' shape and size according to the type of bioactive support was also investigated. Specifically, the commercially available sulfated cellulose nanocrystal (CNC), the salicylic acid functionalized reduced graphene oxide (rGO-SA), and the commercially available titanium dioxide (TiO) were chosen as organic (CNC, rGO-SA) and inorganic (TiO) supports. Then, the antimicrobial activity of the AgNP composites was assessed on clinically relevant multi-drug-resistant bacteria and the fungus . The results show how the formation of Ag nanoparticles on the selected supports provides the resulting composite materials with an effective antibacterial activity.
细菌对传统抗生素的耐药性不断增强，这对人类健康构成了严重的全球紧急情况。银的广谱抗菌活性早已为人所知，纳米级的银显示出增强的抗菌活性。这促使人们开展研究，开发用于临床的银基纳米材料。在这项工作中，描述了使用具有固有抗菌特性的有机和无机载体合成三种不同的银纳米颗粒（AgNP）杂化物的过程。还研究了根据生物活性载体类型对AgNP的形状和尺寸进行调控。具体而言，选择市售的硫酸化纤维素纳米晶体（CNC）、水杨酸功能化的还原氧化石墨烯（rGO-SA）以及市售的二氧化钛（TiO）作为有机（CNC、rGO-SA）和无机（TiO）载体。然后，评估了AgNP复合材料对临床相关的多药耐药细菌和真菌的抗菌活性。结果表明，在所选载体上形成银纳米颗粒如何使所得复合材料具有有效的抗菌活性。
