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探索微乳剂在皮肤给药中的多功能性：机遇与挑战。

Exploring the Versatility of Microemulsions in Cutaneous Drug Delivery: Opportunities and Challenges.

作者信息

Ait-Touchente Zouhair, Zine Nadia, Jaffrezic-Renault Nicole, Errachid Abdelhamid, Lebaz Noureddine, Fessi Hatem, Elaissari Abdelhamid

机构信息

Univ Lyon, Université Claude Bernard Lyon-1, CNRS, ISA-UMR 5280, 69100 Villeurbanne, France.

Univ Lyon, Université Claude Bernard Lyon-1, CNRS, LAGEPP UMR 5007, 69100 Villeurbanne, France.

出版信息

Nanomaterials (Basel). 2023 May 21;13(10):1688. doi: 10.3390/nano13101688.

DOI:10.3390/nano13101688
PMID:37242104
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10222322/
Abstract

Microemulsions are novel drug delivery systems that have garnered significant attention in the pharmaceutical research field. These systems possess several desirable characteristics, such as transparency and thermodynamic stability, which make them suitable for delivering both hydrophilic and hydrophobic drugs. In this comprehensive review, we aim to explore different aspects related to the formulation, characterization, and applications of microemulsions, with a particular emphasis on their potential for cutaneous drug delivery. Microemulsions have shown great promise in overcoming bioavailability concerns and enabling sustained drug delivery. Thus, it is crucial to have a thorough understanding of their formulation and characterization in order to optimize their effectiveness and safety. This review will delve into the different types of microemulsions, their composition, and the factors that affect their stability. Furthermore, the potential of microemulsions as drug delivery systems for skin applications will be discussed. Overall, this review will provide valuable insights into the advantages of microemulsions as drug delivery systems and their potential for improving cutaneous drug delivery.

摘要

微乳剂是新型药物递送系统，在药物研究领域已获得广泛关注。这些系统具有若干理想特性，如透明度和热力学稳定性，这使其适用于递送亲水性和疏水性药物。在这篇全面综述中，我们旨在探讨与微乳剂的配方、表征及应用相关的不同方面，尤其着重于其皮肤给药的潜力。微乳剂在克服生物利用度问题和实现药物持续递送方面已展现出巨大潜力。因此，为优化其有效性和安全性，深入了解其配方和表征至关重要。本综述将深入探讨不同类型的微乳剂、其组成以及影响其稳定性的因素。此外，还将讨论微乳剂作为皮肤应用药物递送系统的潜力。总体而言，本综述将为微乳剂作为药物递送系统的优势及其改善皮肤给药的潜力提供有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/10222322/39718a7283c3/nanomaterials-13-01688-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/10222322/c72aaf501fdc/nanomaterials-13-01688-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/10222322/328f3c5306a8/nanomaterials-13-01688-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/10222322/5f25ee2029c1/nanomaterials-13-01688-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/10222322/69a3110e8574/nanomaterials-13-01688-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/10222322/d363ecb24e65/nanomaterials-13-01688-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/10222322/39718a7283c3/nanomaterials-13-01688-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/10222322/c72aaf501fdc/nanomaterials-13-01688-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/10222322/328f3c5306a8/nanomaterials-13-01688-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/10222322/5f25ee2029c1/nanomaterials-13-01688-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/10222322/69a3110e8574/nanomaterials-13-01688-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/10222322/d363ecb24e65/nanomaterials-13-01688-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88e3/10222322/39718a7283c3/nanomaterials-13-01688-g006.jpg

相似文献

[1]
Exploring the Versatility of Microemulsions in Cutaneous Drug Delivery: Opportunities and Challenges.

Nanomaterials (Basel). 2023-5-21

[2]
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[4]
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[6]
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[9]
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Int J Pharm. 2017-6-30

[10]
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本文引用的文献

[1]
In Vitro and In Vivo Functional Viability, and Biocompatibility Evaluation of Bovine Serum Albumin-Ingrained Microemulsion: A Model Based on Sesame Oil as the Payload for Developing an Efficient Drug Delivery Platform.

Pharmaceuticals (Basel). 2023-4-12

[2]
Topical Delivery of Diacetyl Boldine in a Microemulsion Formulation for Chemoprotection against Melanoma.

Pharmaceutics. 2023-3-10

[3]
Review on Some Confusion Produced by the Bicontinuous Microemulsion Terminology and Its Domains Microcurvature: A Simple Spatiotemporal Model at Optimum Formulation of Surfactant-Oil-Water Systems.

ACS Omega. 2023-3-2

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Release of Tretinoin Solubilized in Microemulsion from Carbopol and Xanthan Gel: In Vitro versus Ex Vivo Permeation Study.

Polymers (Basel). 2023-1-9

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Effect of Penetration Enhancers on Transdermal Delivery of Oxcarbazepine, an Antiepileptic Drug Using Microemulsions.

Pharmaceutics. 2023-1-4

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Nano and Microemulsions for the Treatment of Depressive and Anxiety Disorders: An Efficient Approach to Improve Solubility, Brain Bioavailability and Therapeutic Efficacy.

Pharmaceutics. 2022-12-16

[7]
Development and Skin Penetration Pathway Evaluation Using Confocal Laser Scanning Microscopy of Microemulsions for Dermal Delivery Enhancement of Finasteride.

Pharmaceutics. 2022-12-13

[8]
Exploration of novel drug delivery systems in topical management of osteoarthritis.

Drug Deliv Transl Res. 2023-2

[9]
Phospholipid-Based Microemulsions for Cutaneous Imiquimod Delivery.

Pharmaceuticals (Basel). 2022-4-22

[10]
Superiority of microemulsion-based hydrogel for non-steroidal anti-inflammatory drug transdermal delivery: a comparative safety and anti-nociceptive efficacy study.

Int J Pharm. 2022-6-25

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