Institute of Heart Edson Saad, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, RJ, Brazil.
Department of Clinical Research, National Institute of Cardiology, Rio de Janeiro 22240-006, RJ, Brazil.
Nutrients. 2023 May 16;15(10):2320. doi: 10.3390/nu15102320.
Heart failure (HF) is associated with a reduction of skeletal muscle mass. Whey protein isolate (WPI) has been beneficial in increasing muscle mass and strength, in addition to improving body composition. The goal of this research was to evaluate the effect of WPI on the body composition, muscle mass, and strength of chronic HF patients. For this purpose, twenty-five patients of both genders with predominantly NYHA I functional class and a median age of 65.5 (60.5-71.0) years were used to conduct a randomized, single-blind, placebo-controlled clinical trial and received 30 g per day of WPI for 12 weeks. Anthropometric measurements, body composition analysis, and biochemical exams were performed at the beginning and end of the study. An increase in skeletal muscle mass was observed in the intervention group after 12 weeks. A reduction in waist circumference, body fat percentage, and an increase in skeletal muscle index was observed when compared to the placebo group. No significant effect on muscle strength was observed after 12 weeks of intervention. These data demonstrate that WPI consumption contributed to the increase of skeletal muscle mass, strength, and reduction of body fat in HF patients.
心力衰竭（HF）与骨骼肌质量减少有关。乳清蛋白分离物（WPI）已被证明在增加肌肉质量和力量以及改善身体成分方面有益。本研究的目的是评估 WPI 对慢性 HF 患者的身体成分、肌肉质量和力量的影响。为此，使用了 25 名性别均为 NYHA I 功能级别的患者，中位年龄为 65.5（60.5-71.0）岁，进行了一项随机、单盲、安慰剂对照的临床试验，并在 12 周内每天接受 30 克 WPI。在研究开始和结束时进行了人体测量学测量、身体成分分析和生化检查。干预组在 12 周后观察到骨骼肌质量增加。与安慰剂组相比，腰围、体脂百分比减少，骨骼肌指数增加。干预 12 周后，肌肉力量未见明显变化。这些数据表明，WPI 的摄入有助于增加 HF 患者的骨骼肌质量、力量和减少体脂。
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