de la Roza C, Cano J, Satorre J, Reinoso-suárez F
Mech Ageing Dev. 1986 May;34(3):233-48. doi: 10.1016/0047-6374(86)90076-x.
Light and electron microscopy were used to investigate the morphology of neuropil and neuronal cell bodies of the dorsal lateral geniculate nucleus (LGNd) of aged rats. Light microscopic examination reveals that, despite the optic tract showing signs of degeneration, the LGNd is scarcely affected. Thus, a slight but significant reduction in the diameters of both soma and nuclei is observed in aged neurons of the LGNd. Ultrastructural analysis demonstrates a few degenerating profiles of the neuropil. Neurons resembling relay cells exhibit typical features of aged neurons. Cells showing a very infolded nucleus, most of the ER cisternae connected with the nuclear envelope, abundant free polyribosomes and subsurface cisterns associated with mitochondria are similar to interneurons of adult rats. Therefore, aging and partial loss of visual input appear to induce small changes in the morphology of most of LGNd neurons.
运用光学显微镜和电子显微镜研究老年大鼠背外侧膝状核（LGNd）的神经纤维网和神经元胞体的形态。光学显微镜检查显示，尽管视束有退变迹象，但LGNd几乎未受影响。因此，在LGNd的老年神经元中观察到胞体和细胞核直径略有但显著减小。超微结构分析显示神经纤维网有一些退变的形态。类似中继细胞的神经元呈现出老年神经元的典型特征。细胞核高度折叠、大部分内质网池与核膜相连、有丰富的游离多核糖体以及与线粒体相关的表面下池的细胞类似于成年大鼠的中间神经元。因此，衰老和部分视觉输入丧失似乎会引起LGNd大多数神经元形态的微小变化。
