Starosta Radosław
Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.
Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.
Pharmaceuticals (Basel). 2023 May 19;16(5):766. doi: 10.3390/ph16050766.
Metal complexes feature a wide range of available geometries, diversified lability, controllable hydrolytic stability, and easily available rich redox activity. These characteristics, combined with the specific properties of coordinated organic molecules, result in many different mechanisms of biological action, making each of the myriads of the classes of metal coordination compounds unique. This focused review presents combined and systematized results of the studies of a group of copper(I) (pseudo)halide complexes with aromatic diimines and tris(aminomethyl)phosphines of a general formula [CuX(NN)PR], where X = I or NCS, NN = 2,2'-bipyridyl, 1,10-phenanthroline, 2,9-dimethyl-1,10-phenanthroline or 2,2'-biquinoline, and PR = air-stable tris(aminomethyl)phosphines. The structural and electronic properties of the phosphine ligands and luminescent complexes are discussed. The complexes with 2,9-dimethyl-1,10-phenanthroline, apart from being air- and water-stable, exhibit a very high in vitro antimicrobial activity against the and . Moreover, some of these complexes also show a strong in vitro antitumor activity against human ovarian carcinoma cell lines: MDAH 2774 and SCOV 3, CT26 (mouse colon carcinoma), and A549 (human lung adenocarcinoma) cell lines. The tested complexes are moderately able to induce DNA lesions through free radical processes, however the trends do not reflect observed differences in biological activity.
金属配合物具有多种可用的几何结构、多样的活性、可控的水解稳定性以及易于获得的丰富氧化还原活性。这些特性与配位有机分子的特定性质相结合，产生了许多不同的生物作用机制，使得无数种类的金属配位化合物各具独特性。本综述重点介绍了一组通式为[CuX(NN)PR]的铜（I）（拟）卤化物与芳香二亚胺和三（氨甲基）膦配合物的综合及系统研究结果，其中X = I或NCS，NN = 2,2'-联吡啶、1,10-菲咯啉、2,9-二甲基-1,10-菲咯啉或2,2'-联喹啉，PR = 空气稳定的三（氨甲基）膦。讨论了膦配体和发光配合物的结构和电子性质。与2,9-二甲基-1,10-菲咯啉形成的配合物，除了对空气和水稳定外，对[具体细菌1]和[具体细菌2]表现出非常高的体外抗菌活性。此外，其中一些配合物对人卵巢癌细胞系MDAH 2774和SCOV 3、CT26（小鼠结肠癌）和A549（人肺腺癌）细胞系也显示出很强的体外抗肿瘤活性。测试的配合物能够通过自由基过程适度诱导DNA损伤，然而这些趋势并未反映出观察到的生物活性差异。
