Karges Johannes, Stokes Ryjul W, Cohen Seth M
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States.
Trends Chem. 2021 Jul;3(7):523-534. doi: 10.1016/j.trechm.2021.03.006. Epub 2021 Apr 14.
Metal complexes have been widely used for applications in the chemical and physical sciences due to their unique electronic and stereochemical properties. For decades the use of metal complexes for medicinal applications has been postulated and demonstrated. The distinct characteristics of metal complexes, including their molecular geometries (that are not readily accessed by organic molecules), as well as their ligand exchange, redox, catalytic, and photophysical reactions, give these compounds the potential to interact and react with biomolecules in unique ways and by distinct mechanisms of action. Herein, the potential of metal complexes to act as components bioactive therapeutic compounds is discussed.
金属配合物因其独特的电子和立体化学性质，已在化学和物理科学领域得到广泛应用。几十年来，人们一直在推测并证明金属配合物在医学上的应用。金属配合物的独特特性，包括其分子几何结构（这是有机分子难以实现的）以及它们的配体交换、氧化还原、催化和光物理反应，使这些化合物有可能以独特的方式和不同的作用机制与生物分子相互作用并发生反应。本文讨论了金属配合物作为生物活性治疗化合物成分的潜力。
