Animal Pathology, FARAH Research Center, Faculty of Veterinary Medicine, University of Liège, Sart-Tilman B43, 4000 Liège, Belgium.
Animal Productions, FARAH Research Center, Faculty of Veterinary Medicine, University of Liège, Sart-Tilman B43, 4000 Liège, Belgium.
Viruses. 2023 Apr 25;15(5):1055. doi: 10.3390/v15051055.
Mx proteins are key factors of the innate intracellular defense mechanisms that act against viruses induced by type I/III interferons. The family Peribunyaviridae includes many viruses of veterinary importance, either because infection results in clinical disease or because animals serve as reservoirs for arthropod vectors. According to the evolutionary arms race hypothesis, evolutionary pressures should have led to the selection of the most appropriate Mx1 antiviral isoforms to resist these infections. Although human, mouse, bat, rat, and cotton rat Mx isoforms have been shown to inhibit different members of the Peribunyaviridae, the possible antiviral function of the Mx isoforms from domestic animals against bunyaviral infections has, to our knowledge, never been studied. Herein, we investigated the anti-Schmallenberg virus activity of bovine, canine, equine, and porcine Mx1 proteins. We concluded that Mx1 has a strong, dose-dependent anti-Schmallenberg activity in these four mammalian species.
Mx 蛋白是对抗 I/III 型干扰素诱导病毒的先天细胞内防御机制的关键因素。弹状病毒科包括许多具有兽医重要性的病毒，要么是因为感染导致临床疾病，要么是因为动物作为节肢动物媒介的宿主。根据进化军备竞赛假说，进化压力应该导致选择最适合的 Mx1 抗病毒同工型来抵抗这些感染。尽管已经表明人类、小鼠、蝙蝠、大鼠和棉鼠的 Mx 同工型抑制弹状病毒科的不同成员，但我们所知，从未研究过家畜的 Mx 同工型对 bunyaviral 感染的可能抗病毒功能。在此，我们研究了牛、犬、马和猪 Mx1 蛋白对 Schmallenberg 病毒的活性。我们得出结论，Mx1 在这四个哺乳动物物种中具有强烈的、剂量依赖性的抗 Schmallenberg 活性。
