Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany.
Department of Pathology, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany.
Viruses. 2023 Apr 28;15(5):1087. doi: 10.3390/v15051087.
Skunk amdoparvovirus (, SKAV) is closely related to Aleutian mink disease virus (AMDV) and circulates primarily in striped skunks () in North America. SKAV poses a threat to mustelid species due to reported isolated infections of captive American mink () in British Columbia, Canada. We detected SKAV in a captive striped skunk in a German zoo by metagenomic sequencing. The pathological findings are dominated by lymphoplasmacellular inflammation and reveal similarities to its relative , the causative agent of Aleutian mink disease. Phylogenetic analysis of the whole genome demonstrated 94.80% nucleotide sequence identity to a sequence from Ontario, Canada. This study is the first case description of a SKAV infection outside of North America.
臭鼬细小病毒(Skunk amdoparvovirus,SKAV)与阿勒特海貂细小病毒(Aleutian mink disease virus,AMDV)密切相关,主要在北美的条纹臭鼬()中传播。由于在加拿大不列颠哥伦比亚省有报道称圈养的美洲水貂()发生了孤立感染,因此 SKAV 对鼬科物种构成了威胁。我们通过宏基因组测序在德国动物园的一只圈养条纹臭鼬中检测到了 SKAV。病理学发现主要以淋巴浆细胞性炎症为主,并与它的亲缘病毒,即造成阿勒特海貂病的病原体,具有相似性。全基因组的系统发育分析表明,核苷酸序列的同一性为 94.80%,与来自加拿大安大略省的序列相同。本研究是首例在北美以外地区发生的 SKAV 感染病例描述。