Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, China Agricultural University, Beijing 100193, China.
Viruses. 2023 Apr 30;15(5):1100. doi: 10.3390/v15051100.
Scientific advances have led to the development and production of numerous vaccines and antiviral drugs, but viruses, including re-emerging and emerging viruses, such as SARS-CoV-2, remain a major threat to human health. Many antiviral agents are rarely used in clinical treatment, however, because of their inefficacy and resistance. The toxicity of natural products may be lower, and some natural products have multiple targets, which means less resistance. Therefore, natural products may be an effective means to solve virus infection in the future. New techniques and ideas are currently being developed for the design and screening of antiviral drugs thanks to recent revelations about virus replication mechanisms and the advancement of molecular docking technology. This review will summarize recently discovered antiviral drugs, mechanisms of action, and screening and design strategies for novel antiviral agents.
科学的进步带来了众多疫苗和抗病毒药物的研发和生产，但病毒，包括重新出现和新兴的病毒，如 SARS-CoV-2，仍然是对人类健康的主要威胁。然而，由于其无效性和耐药性，许多抗病毒药物很少用于临床治疗。天然产物的毒性可能较低，并且一些天然产物具有多个靶点，这意味着耐药性较低。因此，天然产物可能是未来解决病毒感染的有效手段。由于最近对病毒复制机制的揭示和分子对接技术的进步，目前正在开发用于设计和筛选抗病毒药物的新技术和新思想。这篇综述将总结最近发现的抗病毒药物、作用机制以及新型抗病毒药物的筛选和设计策略。
