Medical and Pharmaceutical Biotechnology Unit, Center of Research and Assistance in Technology and Design of the State of Jalisco, Guadalajara 44270, Mexico.
CONACYT, Medical and Pharmaceutical Biotechnology Unit, Center of Research and Assistance in Technology and Design of the State of Jalisco, Guadalajara 44270, Mexico.
Viruses. 2023 May 11;15(5):1155. doi: 10.3390/v15051155.
The coronavirus infectious disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been spreading rapidly worldwide, creating a pandemic. This article describes the evaluation of the antiviral activity of nordihydroguaiaretic acid (NDGA), a molecule found in Creosote bush () leaves, against SARS-CoV-2 in vitro. A 35 µM concentration of NDGA was not toxic to Vero cells and exhibited a remarkable inhibitory effect on the SARS-CoV-2 cytopathic effect, viral plaque formation, RNA replication, and expression of the SARS-CoV-2 spike glycoprotein. The 50% effective concentration for NDGA was as low as 16.97 µM. Our results show that NDGA could be a promising therapeutic candidate against SARS-CoV-2.
2019 年冠状病毒病（COVID-19）由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起，已在全球迅速传播，造成大流行。本文描述了对 NDGA（一种存在于熊果叶中的分子）抗 SARS-CoV-2 的体外抗病毒活性的评估。35µM 浓度的 NDGA 对 Vero 细胞无毒，对 SARS-CoV-2 致细胞病变效应、病毒斑形成、RNA 复制和 SARS-CoV-2 刺突糖蛋白表达有显著抑制作用。NDGA 的 50%有效浓度低至 16.97µM。我们的结果表明，NDGA 可能是一种有前途的抗 SARS-CoV-2 治疗候选药物。
