结内栅栏状肌纤维母细胞瘤的细胞病理学特征：病例报告及文献复习。

Cytopathological findings of intranodal palisaded myofibroblastoma: Case report and review of the literature.

机构信息

Pathology Department, Príncipe de Asturias University Hospital, Alcalá de Henares, Spain.

Radiology Department, La Paz University Hospital, Madrid, Spain.

出版信息

Diagn Cytopathol. 2023 Aug;51(8):E248-E254. doi: 10.1002/dc.25172. Epub 2023 May 27.

DOI:10.1002/dc.25172

PMID:37243568

Abstract

INTRODUCTION

Intranodal palisaded myofibroblastoma (IPM) is an exceedingly rare benign mesenchymal tumor of the lymph nodes. Magnetic resonance imaging (MRI) findings are unspecific, which may present diagnostic challenges to fine-needle aspiration cytology (FNAC). The histological and immunohistochemical features of IPM are unique.

CASE REPORT

A previously healthy 40-year-old male patient presented a slow-growing solitary left inguinal mass. FNAC revealed clustered cells within a metachromatic stroma, single spindle cells without atypia, hemosiderin pigment, and siderophages. An MRI showed a central hyperintense septum in fat-suppressed, T2-weighted sequences. The excised lymph node contained central haphazard fascicles of spindle cells with focal nuclear palisading, hemosiderin pigment, extravasated erythrocytes, and hemorrhagic areas. Vimentin and smooth muscle actin were diffusely positive. Amianthoid collagen fibers were not clearly observed.

CONCLUSION

IPM is an extremely rare mesenchymal benign intranodal tumor that should be included in the differential diagnosis of spindle cell lesions in the inguinal region.

摘要

简介

结节内栅栏状肌纤维母细胞瘤（IPM）是一种极其罕见的良性淋巴结间叶性肿瘤。磁共振成像（MRI）表现无特异性，可能对细针抽吸细胞学（FNAC）诊断造成挑战。IPM 的组织学和免疫组织化学特征是独特的。

病例报告

一名既往健康的 40 岁男性患者出现缓慢生长的孤立性左侧腹股沟肿块。FNAC 显示在变色基质中有成群的细胞，单个梭形细胞无异型性，含铁血黄素和含铁血黄素细胞。MRI 在脂肪抑制 T2 加权序列中显示中央高信号隔。切除的淋巴结内含有中央杂乱的梭形细胞束，局灶性核栅栏状排列，含铁血黄素、外渗红细胞和出血区。波形蛋白和平滑肌肌动蛋白弥漫阳性。类弹性纤维未见明显。