Department of Pathology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey.
Diagn Pathol. 2010 Feb 9;5:12. doi: 10.1186/1746-1596-5-12.
Intranodal palisaded myofibroblastoma (IPM) is a benign mesenchymal neoplasm originating from smooth muscle cells and myofibroblasts. It is characterized by spindle cells, amianthoid fibers, and by the proliferation of hemosiderin-containing histiocytes in the lymph node. A nodular lesion was excised from the inguinal region of an 80-year-old male patient. Macroscopic examination of a section of the lesion demonstrated a solid appearance with hemorrhagic areas. Microscopic examination revealed spindle cell proliferation, amianthoid fibers, hemosiderin pigment, and extravasated erythrocytes. Nuclei of the spindle cells displayed a palisaded appearance. Compressed lymphoid tissue was observed around the lesion. With Masson's trichrome, spindle cells stained as smooth muscle, whereas collagen staining was observed in homogeneous eosinophilic accumulations. Neoplastic cells were identified by the presence of vimentin and SMA. The Ki67 index was less than 1%. In light of these results, the case was diagnosed as "intranodal palisaded myofibroblastoma." IPM is an uncommon neoplasm originating from the stromal component of the lymph node. Although IPM is benign, it is frequently confused with metastatic lesions.
结内栅栏状肌纤维母细胞瘤（IPM）是一种起源于平滑肌细胞和肌纤维母细胞的良性间叶性肿瘤。其特征为梭形细胞、非典型性弹性纤维，以及含铁血黄素的组织细胞在淋巴结内增生。一位 80 岁男性患者的腹股沟区切除了一个结节状病变。病变的切片肉眼观察呈实性，伴有出血区。显微镜下观察显示梭形细胞增生、非典型性弹性纤维、含铁血黄素色素和红细胞外溢。梭形细胞的核呈栅栏状排列。病变周围观察到受压的淋巴组织。Masson 三色染色显示梭形细胞呈平滑肌染色，而均质嗜酸性聚集物中可见胶原染色。肿瘤细胞表达波形蛋白和 SMA 可识别。Ki67 指数小于 1%。根据这些结果，该病例诊断为“结内栅栏状肌纤维母细胞瘤”。IPM 是一种起源于淋巴结基质成分的罕见肿瘤。虽然 IPM 是良性的，但它常与转移性病变混淆。
