Department of Rheumatology and Immunology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Department of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Québec, Canada; Gerald Bronfman Department of Oncology, Segal Cancer Centre, Lady Davis Institute and Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Cytokine. 2023 Aug;168:156227. doi: 10.1016/j.cyto.2023.156227. Epub 2023 May 25.
Primary Sjögren's syndrome (pSS) is an autoimmune disease that targets exocrine glands, leading to exocrine dysfunction. Due to its propensity to infect epithelial and B cells, Epstein-Barr virus (EBV) is hypothesized to be related with pSS. Through molecular mimicry, the synthesis of specific antigens, and the release of inflammatory cytokines, EBV contributes to the development of pSS. Lymphoma is the most lethal outcome of EBV infection and the development of pSS. As a population-wide virus, EBV has had a significant role in the development of lymphoma in people with pSS. In the review, we will discuss the possible causes of the disease.
原发性干燥综合征（pSS）是一种自身免疫性疾病，以靶向外分泌腺为特征，导致外分泌功能障碍。由于其倾向于感染上皮细胞和 B 细胞，因此推测 Epstein-Barr 病毒（EBV）与 pSS 有关。通过分子模拟、特定抗原的合成和炎症细胞因子的释放，EBV 有助于 pSS 的发展。淋巴瘤是 EBV 感染和 pSS 发展的最致命结果。作为一种广泛存在于人群中的病毒，EBV 在 pSS 患者的淋巴瘤发展中发挥了重要作用。在综述中，我们将讨论该病的可能病因。
