Institute of Pesticide and Environmental Toxicology, The Key Laboratory of Molecular Biology of Crop Pathogens and Insects, College of Agricultural and Biotechnology, Zhejiang University, Hangzhou, China.
Pest Manag Sci. 2023 Oct;79(10):3926-3933. doi: 10.1002/ps.7586. Epub 2023 Jun 14.
The insecticide carbosulfan is usually applied as a soil treatment or seed-coating agent, and so may be absorbed by crops and pose dietary risks. Understanding the uptake, metabolism and translocation of carbosulfan in crops is conducive to its safe application. In this study, we investigated the distribution of carbosulfan and its toxic metabolites in maize plants at both the tissue and subcellular levels, and explored the uptake and translocation mechanism of carbosulfan.
Carbosulfan was mainly taken up by maize roots via the apoplast pathway, was preferentially distributed in cell walls (51.2%-57.0%) and most (85.0%) accumulated in roots with only weak upward translocation. Carbofuran, the main metabolite of carbosulfan in maize plants, was primarily stored in roots. However, carbofuran could be upwardly translocated to shoots and leaves because of its greater distribution in root-soluble components (24.4%-28.5%) compared with carbosulfan (9.7%-14.5%). This resulted from its greater solubility compared with its parent compound. The metabolite 3-hydroxycarbofuran was found in shoots and leaves.
Carbosulfan could be passively absorbed by maize roots, mainly via the apoplastic pathway, and transformed into carbofuran and 3-hydroxycarbofuran. Although carbosulfan mostly accumulated in roots, its toxic metabolites carbofuran and 3-hydroxycarbofuran could be detected in shoots and leaves. This implies that there is a risk in the use of carbosulfan as a soil treatment or seed coating. © 2023 Society of Chemical Industry.
杀虫剂克百威通常作为土壤处理剂或种子包衣剂使用，因此可能被作物吸收并带来饮食风险。了解克百威在作物中的吸收、代谢和迁移有利于其安全应用。本研究在组织和亚细胞水平上调查了克百威及其有毒代谢物在玉米植株中的分布，并探讨了克百威的吸收和迁移机制。
克百威主要通过质外体途径被玉米根系吸收，优先分布在细胞壁中（51.2%-57.0%），大部分（85.0%）积累在根系中，仅有较弱的向上迁移。克百威在玉米植株中的主要代谢物呋喃丹主要储存在根部。然而，由于呋喃丹在根可溶性成分（24.4%-28.5%）中的分布比克百威（9.7%-14.5%）更大，因此它可以向上迁移到茎和叶中。这是由于其与母体化合物相比具有更大的溶解度。在茎和叶中发现了代谢物 3-羟基呋喃丹。
克百威可被玉米根系被动吸收，主要通过质外体途径，转化为呋喃丹和 3-羟基呋喃丹。虽然克百威主要积累在根部，但在茎和叶中也能检测到其有毒代谢物呋喃丹和 3-羟基呋喃丹。这意味着将克百威用作土壤处理剂或种子包衣存在风险。© 2023 化学工业协会。
