运动联合赖氨酸-肌醇-维生素 B12 可促进特发性身材矮小儿童的身高增长。
Exercise combined with lysine-inositol vitamin B12 promotes height growth in children with idiopathic short stature.
机构信息
Department of Traditional Chinese Medicine, Children's Hospital Affiliated to Zhengzhou University, Henan Key Laboratory of Children's Genetics and Metabolic Diseases, Zhengzhou 450053, Henan, China.
Medical School, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan, China.
出版信息
Growth Horm IGF Res. 2023 Apr-Jun;69-70:101535. doi: 10.1016/j.ghir.2023.101535. Epub 2023 May 16.
OBJECTIVE
This study was aimed to systematically determine the effect of exercise combined with lysine-inositol vitamin B12 (VB12) therapy on the height of children with idiopathic short stature (ISS).
METHODS
Sixty children with ISS were randomly divided into observation and control groups (N = 30). Each group was given lysine-inositol VB12 oral solution (10 mL bid). Simultaneously, the observation group exercised following the "ISS exercise instruction sheet". The height (H), growth velocity (GV), height standard deviation score (HtSDS) and other indicators were compared after 6 and 12 months of intervention, respectively. After 12 months of intervention, the biochemical indicators of the two groups, together with the correlation between the average days of exercise per week and average minutes of exercise per day, GV and serum growth hormone were analyzed.
RESULTS
After 6 and 12 months of treatment, the GV, serum GHRH, GHBP, GH, IGF-1, and IGFBP-3 levels in the observation group were significantly higher than those in the control group, and HtSDS was significantly lower than that in the control group (P<0.01). After 12 months of treatment, the height of the observation group was significantly higher than that of the control group (P<0.05). There was no significant difference in the biochemical indicators between two groups (P>0.05). Average days of exercise per week and average minutes of exercise per day were positively correlated with GV and GHBP levels. Serum GHRH, GH, IGF-1, and IGFBP-3 levels were negatively correlated. Average minutes of exercise per day were negatively correlated with GV and GHBP levels. Serum GHRH, GH, IGF-1, and IGFBP-3 levels were positively correlated.
CONCLUSION
Regular and moderate stretching exercises combined with lysine-inositol VB12 can effectively promote height growth of children with ISS, which is clinically safe. The mechanism promotes serum GHRH, GHBP, GH, IGF-1, and IGFBP-3 levels.
目的
本研究旨在系统地确定运动联合赖氨酸-肌醇维生素 B12（VB12）治疗对特发性身材矮小（ISS）儿童身高的影响。
方法
将 60 例 ISS 患儿随机分为观察组和对照组（N=30）。两组均给予赖氨酸-肌醇 VB12 口服液（10 mL，bid）。同时，观察组按照“ISS 运动指导表”进行运动。分别比较两组患儿干预 6 个月和 12 个月后的身高（H）、生长速度（GV）、身高标准差评分（HtSDS）等指标。干预 12 个月后，分析两组患儿的生化指标，以及每周平均运动天数与每日平均运动分钟数、GV 与血清生长激素的相关性。
结果
治疗 6 个月和 12 个月后，观察组的 GV、血清生长激素释放激素（GHRH）、生长激素结合蛋白（GHBP）、GH、胰岛素样生长因子-1（IGF-1）和 IGF-1 结合蛋白-3（IGFBP-3）水平均显著高于对照组，HtSDS 显著低于对照组（P<0.01）。治疗 12 个月后，观察组身高显著高于对照组（P<0.05）。两组生化指标比较无显著性差异（P>0.05）。每周平均运动天数和每日平均运动分钟数与 GV 和 GHBP 水平呈正相关，与 GHRH、GH、IGF-1 和 IGFBP-3 水平呈负相关。每日平均运动分钟数与 GV 和 GHBP 水平呈负相关，与 GHRH、GH、IGF-1 和 IGFBP-3 水平呈正相关。
结论
定期、适度的伸展运动联合赖氨酸-肌醇 VB12 可有效促进 ISS 患儿身高增长，且临床安全性好。其作用机制可能与促进血清 GHRH、GHBP、GH、IGF-1 和 IGFBP-3 水平有关。
Zotero 插件