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功能社会支持与中年和老年人记忆力之间的关联:对加拿大老龄化纵向研究综合队列的前瞻性分析。

The association between functional social support and memory in middle-aged and older adults: A Prospective Analysis of the Canadian Longitudinal Study on Aging's Comprehensive Cohort.

机构信息

School of Public Health Sciences, University of Waterloo, 200 University Avenue West, N2L 3G1 Waterloo, ON Canada.

School of Public Health Sciences, University of Waterloo, 200 University Avenue West, N2L 3G1 Waterloo, ON Canada; School of Pharmacy, University of Waterloo, 10A Victoria St. S., N2G 1C5 Kitchener, Ontario, Canada.

出版信息

Arch Gerontol Geriatr. 2023 Nov;114:105076. doi: 10.1016/j.archger.2023.105076. Epub 2023 May 23.

Abstract

BACKGROUND

Functional social support (FSS) impacts memory function through biological and psychological pathways. In a national sample of middle-aged and older adults in Canada, we explored the association between FSS and changes in memory over three years and investigated effect modification by age group and sex.

METHODS

We analyzed data from the Comprehensive Cohort of the Canadian Longitudinal Study on Aging (CLSA). FSS was measured with the Medical Outcomes Study - Social Support Survey; memory was measured with combined z-scores from immediate and delayed recall administrations of a modified version of the Rey Auditory Verbal Learning Test. We regressed memory change scores over three years on baseline overall FSS and four FSS subtypes in separate multiple linear regression models, controlling for sociodemographic, health, and lifestyle covariates. We also stratified our models by age group and sex.

RESULT

We found positive associations between higher FSS and improvement in memory score, although only the tangible FSS subtype (availability of practical assistance) was significantly associated with changes in memory (β^ = 0.07; 95% confidence interval = 0.01, 0.14). After stratification by age group and sex, this association remained significant for males, although we found no evidence of effect modification.

CONCLUSION

In a cognitively healthy sample of middle-aged and older adults, we found a statistically significant and positive association between tangible FSS and memory change over three years of follow-up. We did not find adults with low FSS to be at increased risk of memory decline compared to adults with higher FSS.

摘要

背景

功能性社会支持(FSS)通过生物和心理途径影响记忆功能。在加拿大的一项中年和老年人的全国样本中,我们探讨了 FSS 与三年内存忆变化之间的关系,并研究了年龄组和性别对其的影响修饰作用。

方法

我们分析了加拿大纵向老龄化研究(CLSA)综合队列的数据。FSS 采用医疗结局研究-社会支持调查量表进行测量;记忆采用 Rey 听觉言语学习测试的改良版即时和延迟回忆测验的组合 z 分数进行测量。我们在分别的多元线性回归模型中,将三年内存忆变化分数回归到基线总体 FSS 和四个 FSS 亚型上,控制了社会人口统计学、健康和生活方式等协变量。我们还按年龄组和性别对模型进行了分层。

结果

我们发现 FSS 越高,记忆评分的改善越大,但只有有形 FSS 亚型(实际帮助的可用性)与记忆变化显著相关(β^=0.07;95%置信区间 0.01,0.14)。在按年龄组和性别分层后,这种关联在男性中仍然显著,但我们没有发现影响修饰的证据。

结论

在认知健康的中年和老年人样本中,我们发现有形 FSS 与三年随访期间的记忆变化之间存在统计学上显著的正相关。我们没有发现 FSS 较低的成年人比 FSS 较高的成年人更有可能出现记忆衰退的风险。

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