Faculty of Dentistry, Faculty of Medicine Department of Physiology, Centre for the Study of Pain, University of Toronto, Toronto, Canada.
J Oral Rehabil. 2023 Sep;50(9):860-876. doi: 10.1111/joor.13523. Epub 2023 Jun 7.
When the Journal of Oral Rehabilitation was established in 1973, there was very limited understanding of the mechanisms underlying neurally based functions, including those unique to the face, mouth and jaws (e.g. dental pain, taste, chewing, swallowing and salivation). Since that time, technological and other advances have led to new insights into the structure, connectivity and function of cranial nerves and areas of the central nervous system (CNS) involved in oro-facial functions and disorders or related functions (e.g. cognition, emotion, stress, consciousness, sleep, learning and memory). This review focuses on the advances in understanding of the neural basis of oro-facial pain and its control over the past five decades. The review first briefly considers how oro-facial pain conditions are now classified, diagnosed and managed. It then outlines novel insights that have been gained over this period through neuroscience research into the neural basis of these oro-facial pain conditions and the clinical relevance to these insights to the diagnosis and management of these conditions. The review also identifies promising research directions and gaps in knowledge that still need to be addressed to improve the understanding, diagnosis and management of oro-facial pain conditions.
当《口腔修复学杂志》于 1973 年成立时，人们对神经基础功能的机制知之甚少，包括面部、口腔和颌骨特有的功能（如牙痛、味觉、咀嚼、吞咽和唾液分泌）。自那时以来，技术和其他进步使人们对颅神经的结构、连接和功能以及涉及口腔功能和疾病或相关功能（如认知、情绪、压力、意识、睡眠、学习和记忆）的中枢神经系统区域有了新的认识。本综述重点介绍了过去五十年对口颌面部疼痛及其控制的神经基础的理解进展。该综述首先简要考虑了如何对口腔颌面部疼痛状况进行分类、诊断和管理。然后概述了在此期间通过神经科学研究获得的新见解，这些见解涉及这些口腔颌面部疼痛状况的神经基础，以及这些见解对这些状况的诊断和管理的临床相关性。该综述还确定了仍需要解决的有前途的研究方向和知识空白，以提高对口颌面部疼痛状况的理解、诊断和管理。
