单个囊胚冷冻解冻胚胎移植周期中囊胚质量对人类出生性别比的影响。

Effect of blastocyst quality on human sex ratio at birth in a single blastocyst frozen thawed embryo transfer cycle.

机构信息

Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Key Laboratory for Reproductive Medicine of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

出版信息

Gynecol Endocrinol. 2023 Dec;39(1):2216787. doi: 10.1080/09513590.2023.2216787.

DOI:10.1080/09513590.2023.2216787

PMID:37247635

Abstract

RESEARCH QUESTION

To determine whether blastocyst quality affects the sex ratio at birth through a single blastocyst frozen - thawed embryo transfer (SBFET) cycle.

DESIGN

In this retrospective analysis, we examined 3,041 singleton infants born following SBFET between 2017 and 2020 at a single institution. We compared the sex ratios of these infants with respect to the blastocyst quality, embryo growth rate, and morphology.

RESULTS

The main outcomes of this study were that the sex ratio (M/F) at birth of SBFET was 1.24. Mothers >40 years old had a considerably lower sex ratio than mothers <40 years old (0.39 1.23-1.28, < .05). Transplanting high-quality blastocysts significantly increased the proportion of boys born (1.29 0.88, < .05). There were no significant differences in the sex ratio with respect to the inner cell mass (ICM) score and expansion degree. Additionally, a high trophoblastic cell (TE) score resulted in a significantly higher sex ratio than the TE score with C (1.62 1.15 0.85, < .001). Multivariable logistic regression analysis was performed to determine which variables were significant factors affecting sex ratio, and the outcomes were consistent with previous findings.

CONCLUSIONS

Our study indicated that high-quality, especially good TE score, had a higher chance of resulting in a male infant than a female infant.

摘要

研究问题

通过单次囊胚冷冻-解冻胚胎移植（SBFET）周期，确定囊胚质量是否会影响出生时的性别比例。

设计

在这项回顾性分析中，我们检查了 2017 年至 2020 年期间在一家机构接受 SBFET 的 3041 例单胎婴儿。我们比较了这些婴儿的性别比例与囊胚质量、胚胎生长速度和形态的关系。

结果

本研究的主要结果是，SBFET 出生时的性别比例（M/F）为 1.24。年龄>40 岁的母亲的性别比例明显低于年龄<40 岁的母亲（0.39 1.23-1.28， < .05）。移植高质量囊胚显著增加了男婴的出生比例（1.29 0.88， < .05）。内细胞团（ICM）评分和扩张程度与性别比例无显著差异。此外，高滋养层细胞（TE）评分的性别比例显著高于 C 评分的 TE（1.62 1.15 0.85， < .001）。进行多变量逻辑回归分析以确定哪些变量是影响性别比例的显著因素，结果与先前的发现一致。