Fabrication of hierarchical porous ethyl cellulose fibrous membrane by electro-centrifugal spinning for drug delivery systems with excellent integrated properties.

Drug delivery systems (DDSs) based on micro-and nano- fibrous membrane have been developed for decades, in which great attention has been focused on achieving controlled drug release. However, the study on the integrated performance of these drug-loaded membranes in the use of in-vitro drug delivery dressing is lacking, as clinical medication also needs consideration from the perspectives of wound safety and patient convenience. Herein, a trilayered hierarchical porous ethyl cellulose (EC) fibrous membrane based DDS (EC-DDS) was developed by electro-centrifugal spinning. Significantly, the hierarchical porous structure of the EC-DDSs with high specific surface area (34.3 mg) and abundant long-regulative micro-and nano- channels demonstrated its merits in improving the hydrophobicity (long-term splash resistance (CA > 130°) and prolonging the drug release (the release time of ~80 % tetracycline hydrochloride (TCH) prolonged from 10 min to 24 h). Meanwhile, the trilayered EC-DDS also revealed excellent biocompatibility, antibacterial activity, air permeability, moisture permeability, water absorption capacity, mechanical strength, and flexibility. With these excellent integrated features, the EC-DDS could prevent external fluids, avoid infection, and provide comfort. Furthermore, this work also provides a new guide for the high-efficiency fabrication of porous fibrous membranes.