职业接触细胞毒性药物的工人的染色体畸变、姐妹染色单体交换及尿液致突变性

Chromosomal aberrations, SCE and urine mutagenicity in workers occupationally exposed to cytostatic drugs.

作者信息

Pohlová H, Cerná M, Rössner P

出版信息

Mutat Res. 1986 Jul;174(3):213-7. doi: 10.1016/0165-7992(86)90154-5.

Abstract

The genetic risk run by workers occupationally exposed to chemicals, including the newly developed cytostatics, was assessed in large chemical laboratories. The exposed group comprising 38 people consisted of chemists, laboratory assistants and pilot plant workers. The average rate of aberrant cells in peripheral blood lymphocytes (AB.C). was 3.9% and the value of break/cell ratio was 0.046. The group of matched controls (N = 18) was found to have 1.5% of AB.C. and 0.020 breaks/cell. In the exposed group, there were, on average, 8.94 SCEs/cell, and in controls, 5.81. Urine mutagenicity tests on Salmonella typhimurium tester strain TA98 revealed a significant increase of activity in 23 (64%) out of 36 urine samples tested as compared to the control group (N = 19) with 4 (21%) positive urine samples. Strain TA100 showed only a weak response to urine mutagens.

摘要

在大型化学实验室中评估了职业接触化学品（包括新开发的细胞抑制剂）的工人所面临的遗传风险。暴露组由38人组成，包括化学家、实验室助理和中试工厂工人。外周血淋巴细胞中异常细胞的平均比例（AB.C）为3.9%，断裂/细胞比值为0.046。匹配对照组（N = 18）的AB.C为1.5%，断裂/细胞数为0.020。在暴露组中，平均每个细胞有8.94个姐妹染色单体交换（SCE），而对照组为5.81个。对鼠伤寒沙门氏菌测试菌株TA98进行的尿液诱变性测试显示，与对照组（N = 19，4个（21%）尿液样本呈阳性）相比，在测试的36个尿液样本中，有23个（64%）的活性显著增加。菌株TA100对尿液诱变剂仅表现出微弱反应。