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[化学诱变剂对姐妹染色单体交换和染色体畸变形成有效性的定量评估]

[Quantitative evaluation of the effectiveness of the formation of sister chromatid exchanges and chromosome aberrations as affected by chemical mutagens].

作者信息

Shcheglova E G, Chebotarev A N

出版信息

Tsitol Genet. 1984 Jul-Aug;18(4):298-301.

PMID:6474568
Abstract

Dose curves of five chemicals were studied to compare the efficiency of SCE and chromosomal aberration induction by different chemical mutagens. SCEs were found to increase linearly with the dose, whereas chromosomal aberrations--nonlinearly. Using regression coefficients obtained from the dose curves it was found that the efficiency of the studied chemical mutagens in induction of SCEs is 100-300 times as high as that in the induction of chromosomal aberrations.

摘要

研究了五种化学物质的剂量曲线，以比较不同化学诱变剂诱导姐妹染色单体交换（SCE）和染色体畸变的效率。发现SCE随剂量呈线性增加，而染色体畸变则呈非线性增加。利用从剂量曲线获得的回归系数发现，所研究的化学诱变剂诱导SCE的效率比诱导染色体畸变的效率高100 - 300倍。

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1
[Quantitative evaluation of the effectiveness of the formation of sister chromatid exchanges and chromosome aberrations as affected by chemical mutagens].[化学诱变剂对姐妹染色单体交换和染色体畸变形成有效性的定量评估]
Tsitol Genet. 1984 Jul-Aug;18(4):298-301.
2
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4
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