CD4 嵌合抗原受体 T 细胞——不止是辅助细胞。 - Suppr

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超能文献

CD4 CAR T cells - more than helpers.

作者信息

Kohler M Eric, Fry Terry J

机构信息

Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO, USA.

出版信息

Nat Cancer. 2023 Jul;4(7):928-929. doi: 10.1038/s43018-023-00567-2.

DOI:10.1038/s43018-023-00567-2

PMID:37248396

Abstract

摘要

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Nat Cancer. 2023 Jul;4(7):968-983. doi: 10.1038/s43018-023-00570-7. Epub 2023 May 29.

CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses.靶向 CD19 的 CD4 CAR-T 细胞在加剧细胞因子释放综合征方面发挥着关键作用，同时保持长期反应。

J Immunother Cancer. 2023 Jan;11(1). doi: 10.1136/jitc-2022-005878.

Decade-long leukaemia remissions with persistence of CD4 CAR T cells.长达十年的白血病缓解期与 CD4 CAR T 细胞的持续存在。

Nature. 2022 Feb;602(7897):503-509. doi: 10.1038/s41586-021-04390-6. Epub 2022 Feb 2.

Cytotoxic CD4 T cells in cancer: Expanding the immune effector toolbox.肿瘤中的细胞毒性 CD4 T 细胞：扩展免疫效应工具盒。

Immunity. 2021 Dec 14;54(12):2701-2711. doi: 10.1016/j.immuni.2021.11.015.

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity.CAR T 细胞亚群与肿瘤微环境之间的串扰对于持续的细胞毒性活性至关重要。

Sci Immunol. 2021 Mar 26;6(57). doi: 10.1126/sciimmunol.abd4344.

Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients.穿孔素缺陷型 CAR T 细胞重现了患者中观察到的迟发性炎症毒性。

J Clin Invest. 2020 Oct 1;130(10):5425-5443. doi: 10.1172/JCI130059.

Immunobiology of chimeric antigen receptor T cells and novel designs.嵌合抗原受体 T 细胞的免疫生物学和新型设计。

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