糖尿病前期与骨骼健康。
Prediabetes and skeletal health.
机构信息
Division of Geriatrics, Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
出版信息
Curr Opin Endocrinol Diabetes Obes. 2023 Aug 1;30(4):200-205. doi: 10.1097/MED.0000000000000812. Epub 2023 May 29.
PURPOSE OF REVIEW
Type 2 diabetes mellitus (T2D) confers a greater risk of skeletal fragility and fracture. Whether prediabetes is detrimental to bone health is uncertain.
RECENT FINDINGS
We summarize the current data on the associations of prediabetes with bone turnover, bone mineral density, bone quality, bone material properties and fracture risk.
SUMMARY
In cross-sectional studies, prediabetes was associated with lower bone turnover and worse trabecular bone quality. A longitudinal analysis showed that larger increase in insulin resistance (in the absence of T2D) correlated with faster bone loss. Future research to examine the longitudinal associations of prediabetes with bone health parameters is warranted.
目的综述
2 型糖尿病（T2D）使骨骼脆弱和骨折的风险增加。而糖尿病前期是否对骨骼健康有害尚不确定。
最新发现
我们总结了目前关于糖尿病前期与骨转换、骨密度、骨质量、骨材料特性和骨折风险之间关联的研究数据。
总结
在横断面研究中，糖尿病前期与较低的骨转换和较差的小梁骨质量相关。一项纵向分析显示，胰岛素抵抗（无 T2D）的更大增加与更快的骨丢失相关。未来有必要研究糖尿病前期与骨骼健康参数的纵向关联。
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