细胞管和丝：你必须摒弃你所学的知识。

Cytoophidia and filaments: you must unlearn what you have learned.

机构信息

School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, U.K.

出版信息

Biochem Soc Trans. 2023 Jun 28;51(3):1245-1256. doi: 10.1042/BST20221410.

DOI:10.1042/BST20221410

PMID:37248970

Abstract

The nucleotide CTP can be synthesized de novo from UTP via the metabolic enzyme CTP synthase (CTPS). As a textbook enzyme, CTPS has been extensively studied for seven decades. However, it came as a surprise when CTPS was found to form snake-shaped mesoscale cytoophidia in fruit fly cells. Since 2010, more and more studies have demonstrated that CTPS can form cytoophidia within the cells across all three domains of life. Oligomers of CTPS form filaments that are undetectable under light microscopy. This review summarizes our current understanding of cytoophidia and filaments, highlighting some basic features such as conservation, morphology and functions of the two levels of CTPS structures.

摘要

核苷酸 CTP 可以从头合成从 UTP 通过代谢酶 CTP 合酶（CTPS）。作为一种教科书酶，CTPS 已经被广泛研究了七十年。然而，当 CTPS 被发现在果蝇细胞中形成蛇形介观细胞丝状伪足时，人们感到惊讶。自 2010 年以来，越来越多的研究表明，CTPS 可以在所有三个生命领域的细胞内形成细胞丝状伪足。CTPS 的低聚物形成无法在光学显微镜下检测到的纤维。本综述总结了我们目前对细胞丝状伪足和纤维的理解，强调了这两个水平的 CTPS 结构的一些基本特征，如保守性、形态和功能。