发育和代谢线索对细胞凋亡小体形成的影响。

The Impact of Developmental and Metabolic Cues on Cytoophidium Formation.

机构信息

School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

Center for Experimental Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.

出版信息

Int J Mol Sci. 2024 Sep 19;25(18):10058. doi: 10.3390/ijms251810058.

DOI:10.3390/ijms251810058

PMID:39337544

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11432437/

Abstract

The cytoophidium, composed mainly of CTP synthase (CTPS), is a newly discovered dynamic filamentous structure in various organisms such as archaea, bacteria, and humans. These filamentous structures represent a fascinating example of intracellular compartmentation and dynamic regulation of metabolic enzymes. Currently, cytoophidia have been proven to be tightly regulated and highly dynamic, responding rapidly to developmental and metabolic cues and playing a critical role in maintaining cellular homeostasis. In this review, we would like to discuss in detail the characteristics, mechanisms, functions, and potential applications of this conservative but promising organelle.

摘要

细胞丝，主要由 CTP 合成酶（CTPS）组成，是一种在各种生物体中发现的新的动态丝状结构，如古菌、细菌和人类。这些丝状结构代表了细胞内区室化和代谢酶动态调节的一个迷人例子。目前，细胞丝已经被证明是受到严格调节的，并且具有高度的动态性，能够快速响应发育和代谢信号，并在维持细胞内稳态方面发挥关键作用。在这篇综述中，我们将详细讨论这个保守但有前途的细胞器的特征、机制、功能和潜在应用。