嘧啶并[4,5-]喹啉和吡啶并[2,3-]嘧啶的绿色合成——机械化学方法。
A green synthesis of pyrimido[4,5-]quinolines and pyrido[2,3-]pyrimidines a mechanochemical approach.
机构信息
Department of Chemistry, Indian Institute of Technology (BHU), Varanasi 221005, Uttar Pradesh, India.
出版信息
Org Biomol Chem. 2023 Jun 14;21(23):4854-4862. doi: 10.1039/d3ob00626c.
A cost-effective and competent approach has been established for the synthesis of pyrimido[4,5-]quinolines and pyrido[2,3-]pyrimidines a multicomponent reaction of 1,3 diketones (dimedone, barbituric acid, and Meldrum's acid), 6-aminouracil and aromatic aldehyde, through mechanochemical synthesis using a ball-mill. This transformation involves a one pot, catalyst-free, and solvent-free pathway to develop the desired products under mild reaction conditions.
建立了一种经济有效的方法，用于合成嘧啶并[4,5-d]喹啉和吡啶并[2,3-d]嘧啶，该方法是通过球磨的机械化学合成，由 1,3-二酮（二甲基酮、巴比妥酸和 Meldrum's 酸）、6-氨基尿嘧啶和芳香醛的多组分反应。这种转化涉及一锅、无催化剂和无溶剂的途径，在温和的反应条件下开发所需的产物。
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