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新型六氢-5H-噻唑并[2',3':2,3]嘧啶并[4,5-b]喹啉衍生物的高效绿色合成

Efficient and green synthesis of novel hexahydro-5H-thiazolo[2',3':2,3]pyrimido[4,5-b]quinoline derivatives.

作者信息

Tabibi Tooba, Esmaeili Abbas Ali

机构信息

Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, P.O.Box 9177948974, Mashhad, Iran.

出版信息

Mol Divers. 2023 Feb;27(1):477-486. doi: 10.1007/s11030-022-10439-z. Epub 2022 May 8.

DOI:10.1007/s11030-022-10439-z
PMID:35526206
Abstract

Herein, we report a catalyst-free, one-pot three-component reaction of 5-amino-2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-one, aromatic aldehyde, and dimedone in ethylene glycol as a green solvent at 100 °C for the easy access of hexahydro-5H-thiazolo[2',3':2,3]pyrimido[4,5-b]quinoline. Catalyst-free, green solvent, simple procedure, mild reaction conditions, easy work-up procedure, and good to excellent yields are the significant advantages of this protocol.

摘要

在此，我们报道了在100℃下，以乙二醇作为绿色溶剂，5-氨基-2,3-二氢-7H-噻唑并[3,2-a]嘧啶-7-酮、芳香醛和达米酮进行的无催化剂一锅三组分反应，可简便地合成六氢-5H-噻唑并[2',3':2,3]嘧啶并[4,5-b]喹啉。无催化剂、绿色溶剂、操作步骤简单、反应条件温和、后处理简便以及产率良好至优异是该方法的显著优点。

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