BioX Centre, School of Biosciences & Bioengineering, Indian Institute of Technology Mandi, India.
Division of Pediatric Orthopaedic Surgery, Cincinnati Children's Hospital Medical Center, USA.
J Mater Chem B. 2023 Aug 9;11(31):7250-7279. doi: 10.1039/d2tb02052a.
Critical sized bone defects are difficult to manage and currently available clinical/surgical strategies for treatment are not completely successful. Polycaprolactone (PCL) which is a biodegradable and biocompatible thermoplastic can be 3D printed using medical images into patient specific bone implants. The excellent mechanical properties and low immunogenicity of PCL makes it an ideal biomaterial candidate for 3D printing of bone implants. Though PCL suffers from the limitation of being bio-inert. Here we describe the use of PCL as a biomaterial for 3D printing for bone regeneration, and advances made in the field. The specific focus is on the different 3D printing techniques used for this purpose and various modification that can enhance bone regeneration following the development pathways. We further describe the effect of various scaffold characteristics on bone regeneration both and the translational assessment of these 3D printed PCL scaffolds in animal studies. The generated knowledge will help understand cell-material interactions of 3D printed PCL scaffolds, to further improve scaffold chemistry and design that can replicate bone developmental processes and can be translated clinically.
临界尺寸的骨缺损难以处理，目前可用的临床/手术治疗策略并非完全成功。聚己内酯（PCL）是一种可生物降解和生物相容的热塑性塑料，可以使用医学图像 3D 打印成患者特定的骨植入物。PCL 具有优异的机械性能和低免疫原性，使其成为 3D 打印骨植入物的理想生物材料候选物。尽管 PCL 存在生物惰性的局限性。在这里，我们描述了将 PCL 用作生物材料进行 3D 打印以促进骨再生的用途，以及该领域的进展。具体重点是用于此目的的不同 3D 打印技术以及各种可以增强骨再生的改性方法，以及沿着开发途径的骨再生。我们进一步描述了各种支架特性对骨再生的影响，以及这些 3D 打印 PCL 支架在动物研究中的转化评估。所产生的知识将有助于理解 3D 打印 PCL 支架的细胞-材料相互作用，进一步改进支架化学和设计，以复制骨发育过程，并可在临床上转化。
