通过光催化氧化自由基加成硫代酸与烯烃合成α-酮硫醇酯。
Green Synthesis of α-Keton Thiol Ester via Photocatalytic Oxidative Radical Addition of Thioic Acid to Alkene.
机构信息
Shanghai Frontiers Science Center for Drug Target Identification and Drug Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.
Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
出版信息
Org Lett. 2023 Jun 9;25(22):4173-4176. doi: 10.1021/acs.orglett.3c01481. Epub 2023 May 30.
α-Keton sulfides are versatile building blocks in organic synthesis. From thioic acids and alkenes, we were able to develop the direct synthesis of α-keton thiol esters via photocatalytic oxidative radical additions. This reaction well matches the idea of green chemistry. It takes the advantage of thioxanthone as an inexpensive organic photocatalyst, O as a green oxidant, EtOAc as a green solvent, and visible light as a sustainable energy source, and the only byproduct is water.
α-酮硫醚是有机合成中用途广泛的构建模块。通过硫代羧酸和烯烃，我们能够通过光催化氧化自由基加成直接合成α-酮硫醇酯。该反应很好地符合绿色化学的理念。它利用硫杂蒽酮作为廉价的有机光催化剂，O 作为绿色氧化剂，EtOAc 作为绿色溶剂，可见光作为可持续的能源，唯一的副产物是水。
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