Department of Pathology and Laboratory Medicine, East Carolina University/ECU Health, Greenville, NC.
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN.
Am J Dermatopathol. 2023 Jul 1;45(7):466-469. doi: 10.1097/DAD.0000000000002462.
Lymphedematous fibroepithelial polyps are rare proliferations involving the glans penis typically associated with chronic condom catheter usage. To the best of our knowledge, less than 20 cases have been reported in the literature with relatively similar clinical presentation. Herein, we report a case of lymphedematous fibroepithelial polyp not associated with condom usage in a 74-year-old man treated with surgical excision. On histopathological examination, the lesion displayed a hypocellular proliferation of spindled and stellate fibroblasts with intermixed Touton-like giant cells embedded within an edematous stroma with thickened vasculature. Immunohistochemical profiling exhibits strong immunoreactivity for smooth muscle actin, weak positivity for factor XIIIa, and no reactivity for CD34 or desmin. We also conducted a review of the reported range of clinical and histopathological features of this entity in addition to the various hypotheses regarding its pathogenesis. We hope to increase awareness and accurate diagnosis of this entity, which could affect clinical management.
淋巴水肿性纤维上皮性息肉是一种罕见的阴茎头增殖性病变，通常与慢性避孕套导管使用有关。据我们所知，文献中报道的病例不足 20 例，临床表现较为相似。在此，我们报告一例与避孕套使用无关的 74 岁男性患者的淋巴水肿性纤维上皮性息肉病例，该患者接受了手术切除治疗。组织病理学检查显示，病变呈细胞稀疏的梭形和星状成纤维细胞增生，其间嵌入伴有增厚血管的水肿基质内的托顿样巨细胞。免疫组织化学分析显示平滑肌肌动蛋白强阳性，因子 XIIIa 弱阳性，CD34 和结蛋白阴性。我们还回顾了该实体的报告临床和组织病理学特征范围，以及关于其发病机制的各种假说。我们希望提高对该实体的认识和准确诊断，这可能会影响临床管理。
