Hospital de Clínicas de Porto Alegre, Serviço de Endocrinologia, Porto Alegre, RS, Brasil.
Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Departamento de Clínica Médica, Programa de Pós-graduação em Ciências Médicas: Endocrinologia, Porto Alegre, RS, Brasil.
Arch Endocrinol Metab. 2023 May 25;67(5):e000624. doi: 10.20945/2359-3997000000624.
The objective of this study was to investigate the association between SNPs in the and genes and diabetic retinopathy (DR).
This study comprised 603 patients with type 2 diabetes mellitus (T2DM) and DR (cases) and 388 patients with T2DM for more than 10 years and without DR (controls). The rs639225 (A/G) and rs638203 (A/G) SNPs and the rs4324901 (G/T) and rs2507800 (T/A) SNPs were genotyped by real-time PCR using TaqMan MGB probes.
The G/G genotype of the rs639225/, the G/G genotype of the rs638203/ and the T allele of the rs4324901/ SNPs were associated with protection against DR after adjustment for age, glycated hemoglobin, gender, and presence of hypertension (P = 0.042, P = 0.003, and P = 0.028, respectively). No association was found between the rs2507800/ SNP and DR.
We demonstrated, for the first time, the association of rs638203 and rsrs939225 SNPs and rs4324901 SNP with protection against DR in a Brazilian population.
本研究旨在探讨 和 基因中的 SNPs 与糖尿病视网膜病变（DR）之间的关联。
本研究纳入了 603 例 2 型糖尿病伴 DR（病例组）和 388 例 2 型糖尿病超过 10 年且无 DR（对照组）的患者。采用 TaqMan MGB 探针实时 PCR 法检测 rs639225（A/G）和 rs638203（A/G）SNP 以及 rs4324901（G/T）和 rs2507800（T/A）SNP 的基因型。
经年龄、糖化血红蛋白、性别和高血压状况校正后，rs639225/ 的 G/G 基因型、rs638203/ 的 G/G 基因型和 rs4324901/ 的 T 等位基因与 DR 的发生呈负相关（P = 0.042、P = 0.003 和 P = 0.028）。rs2507800/ SNP 与 DR 之间无相关性。
本研究首次在巴西人群中证实了 rs638203 和 rsrs939225 SNP 以及 rs4324901 SNP 与 DR 发生的相关性。
