基因和 基因的多态性与巴西人群糖尿病性视网膜病变的保护有关。
Polymorphisms in and genes are associated with protection against diabetic retinopathy in a Brazilian population.
机构信息
Hospital de Clínicas de Porto Alegre, Serviço de Endocrinologia, Porto Alegre, RS, Brasil.
Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Departamento de Clínica Médica, Programa de Pós-graduação em Ciências Médicas: Endocrinologia, Porto Alegre, RS, Brasil.
出版信息
Arch Endocrinol Metab. 2023 May 25;67(5):e000624. doi: 10.20945/2359-3997000000624.
OBJECTIVE
The objective of this study was to investigate the association between SNPs in the and genes and diabetic retinopathy (DR).
SUBJECTS AND METHODS
This study comprised 603 patients with type 2 diabetes mellitus (T2DM) and DR (cases) and 388 patients with T2DM for more than 10 years and without DR (controls). The rs639225 (A/G) and rs638203 (A/G) SNPs and the rs4324901 (G/T) and rs2507800 (T/A) SNPs were genotyped by real-time PCR using TaqMan MGB probes.
RESULTS
The G/G genotype of the rs639225/, the G/G genotype of the rs638203/ and the T allele of the rs4324901/ SNPs were associated with protection against DR after adjustment for age, glycated hemoglobin, gender, and presence of hypertension (P = 0.042, P = 0.003, and P = 0.028, respectively). No association was found between the rs2507800/ SNP and DR.
CONCLUSION
We demonstrated, for the first time, the association of rs638203 and rsrs939225 SNPs and rs4324901 SNP with protection against DR in a Brazilian population.
目的
本研究旨在探讨 和 基因中的 SNPs 与糖尿病视网膜病变（DR）之间的关联。
对象与方法
本研究纳入了 603 例 2 型糖尿病伴 DR（病例组）和 388 例 2 型糖尿病超过 10 年且无 DR（对照组）的患者。采用 TaqMan MGB 探针实时 PCR 法检测 rs639225（A/G）和 rs638203（A/G）SNP 以及 rs4324901（G/T）和 rs2507800（T/A）SNP 的基因型。
结果
经年龄、糖化血红蛋白、性别和高血压状况校正后，rs639225/ 的 G/G 基因型、rs638203/ 的 G/G 基因型和 rs4324901/ 的 T 等位基因与 DR 的发生呈负相关（P = 0.042、P = 0.003 和 P = 0.028）。rs2507800/ SNP 与 DR 之间无相关性。
结论
本研究首次在巴西人群中证实了 rs638203 和 rsrs939225 SNP 以及 rs4324901 SNP 与 DR 发生的相关性。
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