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RPS Brazilian Birth Cohorts Consortium (Ribeirão Preto, Pelotas and São Luís): history, objectives and methods.RPS 巴西出生队列联盟（里贝朗普雷图、佩洛塔斯和圣路易斯）：历史、目标和方法。
Cad Saude Publica. 2021 Apr 30;37(4):e00093320. doi: 10.1590/0102-311X00093320. eCollection 2021.
2
Alternative pediatric metabolic syndrome definitions impact prevalence estimates and socioeconomic gradients.替代性儿童代谢综合征定义影响患病率估计及社会经济梯度。
Pediatr Res. 2021 Sep;90(3):694-700. doi: 10.1038/s41390-020-01331-3. Epub 2021 Jan 14.
3
The prevalence of pediatric metabolic syndrome-a critical look on the discrepancies between definitions and its clinical importance.儿童代谢综合征的流行情况-对定义之间的差异及其临床重要性的批判性观察。
Int J Obes (Lond). 2021 Jan;45(1):12-24. doi: 10.1038/s41366-020-00713-1. Epub 2020 Nov 18.
4
Prevalence of Metabolic Syndrome by different definitions, and its association with type 2 diabetes, pre-diabetes, and cardiovascular disease risk in Brazil.不同定义下代谢综合征的流行情况，及其与巴西 2 型糖尿病、糖尿病前期和心血管疾病风险的关系。
Diabetes Metab Syndr. 2020 Sep-Oct;14(5):1217-1224. doi: 10.1016/j.dsx.2020.05.043. Epub 2020 Jul 12.
5
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Cad Saude Publica. 2020;36(7):e00164519. doi: 10.1590/0102-311x00164519. Epub 2020 Jul 3.
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Understanding Puberty and Its Measurement: Ideas for Research in a New Generation.理解青春期及其测量：新一代研究的思路。
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Pathophysiology of the metabolic syndrome.代谢综合征的病理生理学
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The Metabolic Syndrome in Children and Adolescents: Shifting the Focus to Cardiometabolic Risk Factor Clustering.儿童和青少年的代谢综合征：将重点转移到心血管代谢危险因素聚集。
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基于三种诊断定义的青少年代谢综合征患病率：一项横断面研究。

Prevalence of metabolic syndrome in adolescents based on three diagnostic definitions: a cross-sectional study.

机构信息

Programa de Pós-graduação em Nutrição, Universidade Federal de Pernambuco, Recife, PE, Brasil,

Departamento de Saúde Pública, Universidade Federal do Maranhão, São Luís, MA, Brasil.

出版信息

Arch Endocrinol Metab. 2023 May 25;67(5):e000634. doi: 10.20945/2359-3997000000634.

DOI:10.20945/2359-3997000000634
PMID:37249462
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10665060/
Abstract

OBJECTIVE

There is no consensus as to the best criterion for the evaluation of metabolic syndrome (MS), impairing the estimation of its prevalence. This study aims to compare MS estimates using three recommended definitions for adolescents based on a cross-sectional study nested in the Consortium of Brazilian Birth Cohorts in São Luís, Maranhão.

SUBJECTS AND METHODS

A total of 2,515 adolescents aged between 18 and 19 years were evaluated. The criteria of International Diabetes Federation (IDF) and National Cholesterol Education Program Panel III (NCEP-ATP) modified by Cook and cols. (2003) and De Ferranti and cols. (2004) defined SM. To compare the estimates of MS prevalence, the chi-square, Fisher´s exact and Cohen´s Kappa index tests were used.

RESULTS

Among the 2,064 participants evaluated in the final sample. The prevalence of MS ranged from 4.2% (95% CI: 3.3-5.1) to 10.2% (95% CI: 8.8-11.4). When comparing the estimates of MS prevalence in the total sample and by sex, a statistically significant difference was observed. The agreement between the criteria ranged from 0.42 (CI 95%: 0.35-0.49) to 0.55 (CI 95%: 0.48-0.62) in the total sample, 0.33 (CI 95%: 0.24-0.42) to 0.59 (95%CI: 0.47-0.71) among boys and 0.39 (95% CI: 0.26-0.52) to 0.54 (95% CI: 0.44-0.64) among girls.

CONCLUSION

Different criteria provide different estimates for the prevalence of MS in adolescents, reflecting the importance of establishing a consensus.

摘要

目的

代谢综合征（MS）的评估尚无最佳标准，这影响了其流行率的估计。本研究旨在通过嵌套在圣路易斯，马腊尼昂的巴西出生队列联盟中的横断面研究，比较三种推荐的青少年 MS 定义的估计。

受试者和方法

共评估了 2515 名年龄在 18 至 19 岁之间的青少年。国际糖尿病联合会（IDF）和国家胆固醇教育计划专家小组（NCEP-ATP）的标准（由 Cook 等人修改）（2003 年）和 De Ferranti 等人（2004 年）定义为 SM。为了比较 MS 流行率的估计值，使用了卡方检验、Fisher 确切检验和 Cohen Kappa 指数检验。

结果

在最终样本中评估了 2064 名参与者。MS 的患病率范围为 4.2%（95%CI：3.3-5.1）至 10.2%（95%CI：8.8-11.4）。当比较总样本和性别之间的 MS 流行率估计值时，观察到统计学上的显著差异。标准之间的一致性在总样本中为 0.42（95%CI：0.35-0.49）至 0.55（95%CI：0.48-0.62），在男孩中为 0.33（95%CI：0.24-0.42）至 0.59（95%CI：0.47-0.71），在女孩中为 0.39（95%CI：0.26-0.52）至 0.54（95%CI：0.44-0.64）。

结论

不同的标准为青少年 MS 的流行率提供了不同的估计值，反映了达成共识的重要性。