Anton-Păduraru Dana-Teodora, Mindru Dana Elena, Stănescu Raluca Stefania, Trofin Felicia, Cobuz Claudiu, Cobuz Maricela, Sur Lucia Maria, Petroaie Antoneta, Slănină Ana Maria, Manole Mihaela, Bocec Ana Simona, Cosmescu Adriana
Department of Mother and Child Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
"Sf. Maria" Children Emergency Hospital, 700309 Iasi, Romania.
Children (Basel). 2025 Apr 8;12(4):482. doi: 10.3390/children12040482.
BACKGROUND/OBJECTIVES: One of the metabolic complications of obesity is known as Metabolic Syndrome (MetS). This narrative review aims to synthesize current research on MetS in young populations, identify knowledge gaps, and guide future studies and funding priorities. It provides evidence-based insights into screening, diagnosis, and treatment, offering practical guidance for healthcare professionals.
A comprehensive search of the literature was conducted to identify relevant studies on obesity in MetS in PubMed and Google Academic electronic database. The search was performed using a combination of "obesity", "complications", "metabolic syndrome", "children", and "adolescents" keywords. Studies were selected based on predefined inclusion and exclusion criteria to ensure relevance and methodological rigor.
The lack of universally accepted diagnostic criteria for MetS in children has led to inconsistencies in its definition across medical literature. Irrespective of the chosen diagnostic approach, the prevalence of MetS in children and adolescents has exhibited a concurrent rise with the increasing rates of obesity in this age group. The pathophysiology of MetS remains incompletely understood, with ongoing discussions on the interplay of genetic, epigenetic, environmental, dietary, and lifestyle factors. Screening for MetS is recommended for overweight and obese children.
Establishing global, consensus-driven criteria that account for ethnicity, gender, and age would enhance diagnostic accuracy and treatment approaches. The prevention of excessive weight among children and adolescents stands as a paramount objective within modern society's healthcare system. Considering the complexity of the disease and the treatment, the team must be multidisciplinary.
背景/目的：肥胖的代谢并发症之一是代谢综合征（MetS）。本叙述性综述旨在综合当前关于年轻人群中代谢综合征的研究，找出知识空白，并指导未来的研究和资金优先事项。它为筛查、诊断和治疗提供基于证据的见解，为医疗保健专业人员提供实用指导。
在PubMed和谷歌学术电子数据库中对文献进行全面检索，以确定关于代谢综合征中肥胖的相关研究。使用“肥胖”“并发症”“代谢综合征”“儿童”和“青少年”等关键词组合进行检索。根据预先定义的纳入和排除标准选择研究，以确保相关性和方法的严谨性。
儿童代谢综合征缺乏普遍接受的诊断标准，导致医学文献中其定义不一致。无论选择何种诊断方法，儿童和青少年中代谢综合征的患病率都随着该年龄组肥胖率的上升而同步上升。代谢综合征的病理生理学仍未完全理解，关于遗传、表观遗传、环境、饮食和生活方式因素之间的相互作用仍在讨论中。建议对超重和肥胖儿童进行代谢综合征筛查。
建立考虑种族、性别和年龄的全球共识驱动标准将提高诊断准确性和治疗方法。预防儿童和青少年超重是现代社会医疗保健系统的首要目标。考虑到该疾病及其治疗的复杂性，团队必须是多学科的。
