Quan Chuansong, Liu Qinghua, Yu Lijuan, Li Chunjing, Nie Kaixiao, Ding Guoyong, Zhou Hong, Wang Xinli, Sun Wenwen, Wang Huiliang, Yue Maokui, Wei Li, Zheng Wenjun, Lyu Qiang, Xing Weijia, Zhang Zhenjie, Carr Michael J, Zhang Hong, Shi Weifeng
Department of Infectious Disease, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, China.
Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China.
iScience. 2023 May 4;26(6):106799. doi: 10.1016/j.isci.2023.106799. eCollection 2023 Jun 16.
The impairment of antibody-mediated immunity is a major factor associated with fatal cases of severe fever with thrombocytopenia syndrome (SFTS). By collating the clinical diagnosis reports of 30 SFTS cases, we discovered the overproliferation of monoclonal plasma cells (MCP cells, CD38cLambdacKappa) in bone marrow, which has only been reported previously in multiple myeloma. The ratio of CD38cLambda versus CD38cKappa in SFTS cases with MCP cells was significantly higher than that in normal cases. MCP cells presented transient expression in the bone marrow, which was distinctly different from multiple myeloma. Moreover, the SFTS patients with MCP cells had higher clinical severity. Further, the overproliferation of MCP cells was also observed in SFTS virus (SFTSV)-infected mice with lethal infectious doses. Together, SFTSV infection induces transient overproliferation of monoclonal lambda-type plasma cells, which have important implications for the study of SFTSV pathogenesis, prognosis, and the rational development of therapeutics.
抗体介导的免疫功能受损是与严重发热伴血小板减少综合征（SFTS）致死病例相关的主要因素。通过整理30例SFTS病例的临床诊断报告，我们发现骨髓中存在单克隆浆细胞（MCP细胞，CD38cλκ）过度增殖的情况，此前仅在多发性骨髓瘤中报道过。存在MCP细胞的SFTS病例中CD38cλ与CD38cκ的比例显著高于正常病例。MCP细胞在骨髓中呈短暂表达，这与多发性骨髓瘤明显不同。此外，存在MCP细胞的SFTS患者临床严重程度更高。此外，在感染致死剂量SFTS病毒（SFTSV）的小鼠中也观察到了MCP细胞的过度增殖。总之，SFTSV感染诱导单克隆λ型浆细胞短暂过度增殖，这对SFTSV发病机制、预后及治疗药物的合理开发研究具有重要意义。
