Tang Jinsong, Yang Jie, Liu Yi, Liu Xiaocong, Li Ling, Sun Yunkai, Jin Jieyin, Fang Yehong, Zhou Zitang, Wang Yunfei, Liu Yueheng, Chen Wei, McNeill Ann, Kelly Brian C, Cohen Joanna E, Liao Yanhui
Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China.
Department of Big Data in Health Science School of Public Health, and Center of Clinical Big Data and Analytics of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China.
EClinicalMedicine. 2023 May 18;60:102009. doi: 10.1016/j.eclinm.2023.102009. eCollection 2023 Jun.
China has approximately 300 million current smokers, and smoking cessation services are limited. This study aimed to assess the efficacy of a Cognitive Behavioral Theory-based smoking cessation intervention ('WeChat WeQuit') via the most popular social media platform in China, WeChat.
A parallel, single-blind, two-arm randomised controlled trial was conducted via WeChat between March 19, 2020 and November 16, 2022. Chinese-speaking adult smokers (n = 2000) willing to quit within one month were recruited and randomised in a 1:1 ratio. The intervention group (n = 1005) received the 'WeChat WeQuit' program and the control group (n = 955) received control messages for 14 weeks (2-week prequit and 12-week postquit). Participants were followed up to 26 weeks after the quit date. The primary outcome was self-reported continuous smoking abstinence rate, biochemically validated at 26 weeks. The secondary outcomes were self-reported 7-day and continuous abstinence rates at 6 months. All analyses were by intention to treat. The trial is registered at ClinicalTrials.gov (NCT03169686).
By intention-to-treat analysis, the biochemically verified 26-week continuous abstinence rate was 11.94% in the intervention group and 2.81% in the control group (OR = 4.68, 95% CI: 3.07-7.13, < 0.0001). The self-reported 7-day abstinence rates ranged from 39.70% at week 1-32.04% at week 26 for the intervention group and 14.17%-11.86% in the control group for weeks 1 and 26, respectively; the self-reported continuous abstinence rates at weeks 1 and 26 ranged from 34.33% to 24.28% and 9.65% to 6.13% in the intervention group and the control group respectively (all < 0.0001). Participants with low nicotine dependence or previous quit attempts were more likely to successfully quit smoking.
The 'WeChat WeQuit' intervention significantly increased smoking abstinence rates at 6 months and should be considered for treatment-seeking smokers in China.
The research is supported by the Natural Science Foundation of Hunan Province (2020JJ4794, YLiao), the K.C. Wong Postdoctoral Fellowship for YLiao to study at King's College London, and China Medical Board (CMB) Open Competition Program (grant no. 15-226, 22-485, YLiao).
中国目前约有3亿吸烟者，戒烟服务有限。本研究旨在通过中国最受欢迎的社交媒体平台微信，评估基于认知行为理论的戒烟干预措施（“微信我戒烟”）的效果。
于2020年3月19日至2022年11月16日通过微信进行了一项平行、单盲、双臂随机对照试验。招募了愿意在一个月内戒烟的会说中文的成年吸烟者（n = 2000），并按1:1的比例随机分组。干预组（n = 1005）接受“微信我戒烟”计划，对照组（n = 955）在14周内（戒烟前2周和戒烟后12周）接收对照信息。在戒烟日期后对参与者进行长达26周的随访。主要结局是自我报告的持续戒烟率，在26周时进行生化验证。次要结局是自我报告的6个月时7天和持续戒烟率。所有分析均采用意向性分析。该试验已在ClinicalTrials.gov注册（NCT03169686）。
通过意向性分析，干预组经生化验证的26周持续戒烟率为11.94%，对照组为2.81%（OR = 4.68，95%CI：3.07 - 7.13，P < 0.0001）。干预组自我报告的7天戒烟率在第1周为39.70%至第26周为32.04%，对照组在第1周和第26周分别为14.17% - 11.86%；干预组和对照组在第1周和第26周的自我报告持续戒烟率分别为34.33%至24.28%和9.65%至6.13%（均P < 0.0001）。尼古丁依赖程度低或以前有过戒烟尝试的参与者更有可能成功戒烟。
“微信我戒烟”干预措施显著提高了6个月时 的戒烟率，对于在中国寻求治疗的吸烟者应考虑采用该措施。
本研究得到湖南省自然科学基金（2020JJ4794，廖勇力）、廖勇力在伦敦国王学院学习的王宽诚博士后奖学金以及中国医学委员会（CMB）开放竞争项目（资助编号15 - 226、22 - 485，廖勇力）的支持。
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