Dubé Karine, Villa Thomas J, Taylor Jeff, Kaytes Andy, Moore David J, Little Susan J, Chaillon Antoine, Smith Davey M, Gianella Sara
Division of Infectious Diseases and Global Public Health, School of Medicine, University of California San Diego, La Jolla, CA.
AntiViral Research Center, University of California San Diego, San Diego, CA.
Pathog Immun. 2023 May 24;8(1):1-16. doi: 10.20411/pai.v8i1.583. eCollection 2023.
Initiated in 2017 after extensive community engagement, the Last Gift program enrolls altruistic volunteers willing to donate their cells and tissues at the end of life to allow studies on HIV reservoir dynamics across anatomical sites. As the Last Gift team received tissue requests outside the scope of HIV cure research, we noticed the absence of guiding frameworks to help prioritize the use of altruistically donated human biological materials. In this commentary, we present a proposed framework for prioritizing the use of donated human biological materials within and outside the end-of-life (EOL) HIV cure research context, using the Last Gift study as an example. First, we discuss regulatory and policy considerations, and highlight key ethical values to guide prioritization decisions. Second, we present our prioritization framework and share some of our experiences prioritizing requests for donated human biological materials within and outside EOL HIV cure research.
“最后礼物”项目于2017年在广泛的社区参与之后启动，招募了愿意在生命末期捐赠细胞和组织的利他志愿者，以开展跨解剖部位的HIV病毒库动态研究。由于“最后礼物”团队收到了HIV治愈研究范围之外的组织请求，我们注意到缺乏指导框架来帮助确定利他捐赠的人类生物材料的使用优先级。在这篇评论中，我们以“最后礼物”研究为例，提出了一个在临终（EOL）HIV治愈研究背景内外确定捐赠人类生物材料使用优先级的框架。首先，我们讨论监管和政策考量，并强调指导优先级决策的关键伦理价值。其次，我们展示我们的优先级框架，并分享一些我们在临终HIV治愈研究内外确定捐赠人类生物材料请求优先级的经验。
