Horio T, Shimura T, Hanada M, Shimokochi M
Neurosci Res. 1986 May;3(4):311-20. doi: 10.1016/0168-0102(86)90023-4.
Multiple unit activities (MUAs) were recorded from the medial preoptic area (MPO) during copulatory behavior in freely moving male rats. The baseline firing rate in the male MPO was 19.6 spikes/s +/- 7.1 S.E. (n = 14), and it was increased by 36.7% when a female rat was introduced (26.8 spikes/s +/- 8.9 S.E., n = 14). The firing rate remained elevated until ejaculation. The maximum firing rate (53.5 spikes/s +/- 16.7 S.E., n = 14) was obtained specifically during pursuit-mounting behavior. This high frequency firing with pursuit-mounting behavior was, however, immediately inhibited for 8.2 s +/- 2.1 S.E. (n = 14) when mounting was followed by intromission. The firing-inhibition was further prolonged (120.9 s +/- 44.6 S.E., n = 14) when ejaculation was performed after mounting and intromission. In cases where mounting was elicited alone, a firing-inhibition was not observed and the firing rate after mounting returned to the average firing rate during copulatory behavior. These results suggest that the MPO neurons may play a major role in pursuit-mounting, intromission and ejaculation.
在自由活动的雄性大鼠交配行为期间，从内侧视前区（MPO）记录了多单位活动（MUAs）。雄性MPO的基线放电频率为19.6个脉冲/秒±7.1标准误（n = 14），当引入雌性大鼠时增加了36.7%（26.8个脉冲/秒±8.9标准误，n = 14）。放电频率在射精前一直保持升高。最大放电频率（53.5个脉冲/秒±16.7标准误，n = 14）专门在追逐-骑跨行为期间获得。然而，当骑跨行为后紧接着插入时，这种与追逐-骑跨行为相关的高频放电立即被抑制8.2秒±2.1标准误（n = 14）。当在骑跨和插入后射精时，放电抑制进一步延长（120.9秒±44.6标准误，n = 14）。在仅引发骑跨行为的情况下，未观察到放电抑制，骑跨行为后的放电频率恢复到交配行为期间的平均放电频率。这些结果表明，MPO神经元可能在追逐-骑跨、插入和射精中起主要作用。
