Sabah Zia, Wani Javed, Deajim Mosab, Al Zomia Ahmed S, Asiri Abdullah, Alqahtani Ali A, Alansari Wasna, Alwan Amin, Al Qahtani Ryan M, Raj Berin
Medicine, King Khalid University, Abha, SAU.
Internal Medicine, King Khalid University, Abha, SAU.
Cureus. 2023 Apr 26;15(4):e38147. doi: 10.7759/cureus.38147. eCollection 2023 Apr.
Background Magnesium is an essential micronutrient for people and is crucial in maintaining healthy cardiac function. It functions as a cofactor in a number of the body's enzyme systems, and myocardial cells are one of its target tissues. The upkeep of the myocardium's normal functional integrity depends on a lot of things including magnesium ions. Magnesium plays an important role in the pathophysiology of cardiovascular disorders. Aim This study aims to estimate serum magnesium levels and their correlation with cardiac complications and mortality in patients with acute myocardial infarction (AMI). Methods Patients with acute myocardial infarction who visited the Prince Faisal Bin Khalid Cardiac Center within 12 hours of the onset of symptoms were the subjects of this study. On the first and fifth days following admission, the level of serum magnesium was assessed. Statistical Package for Social Sciences (SPSS) version 20 (IBM SPSS Statistics, Armonk, NY) was used to analyze the collected data. Results The current study comprised 160 patients with acute myocardial infarction; there were 84 (52.5%) who experienced a low level of serum magnesium on admission. Significantly higher proportions of patients who experienced low magnesium levels had diabetes mellitus (P=0.0072) and a history of diuretics (P=0.03) and were administrated beta-blockers (P=0.01), calcium channel blockers (P=0.04), and statins (P=0.007) after admission. Significantly higher proportions of patients with low serum magnesium experienced atrial fibrillation (P=0.03), angina (P=0.03), and cardiogenic shock (P=0.003). Conclusion Low magnesium levels are associated with poor outcomes in most patients admitted with acute myocardial infarction.
背景 镁是人体必需的微量营养素，对维持心脏功能健康至关重要。它在人体许多酶系统中作为辅助因子发挥作用，心肌细胞是其靶组织之一。心肌正常功能完整性的维持取决于许多因素，包括镁离子。镁在心血管疾病的病理生理学中起着重要作用。目的 本研究旨在评估急性心肌梗死（AMI）患者的血清镁水平及其与心脏并发症和死亡率的相关性。方法 本研究的对象为症状发作后12小时内就诊于费萨尔·本·哈立德王子心脏中心的急性心肌梗死患者。在入院后的第一天和第五天评估血清镁水平。使用社会科学统计软件包（SPSS）20版（IBM SPSS Statistics，纽约州阿蒙克）分析收集的数据。结果 本研究包括160例急性心肌梗死患者；其中84例（52.5%）入院时血清镁水平较低。血清镁水平低的患者中，糖尿病患者（P=0.0072）、有使用利尿剂史的患者（P=0.03）以及入院后使用β受体阻滞剂（P=0.01）、钙通道阻滞剂（P=0.04）和他汀类药物（P=0.007）的患者比例显著更高。血清镁水平低的患者发生心房颤动（P=0.03）、心绞痛（P=0.03）和心源性休克（P=0.003）的比例显著更高。结论 大多数急性心肌梗死入院患者的低镁水平与不良预后相关。
