Gogineni Rajyalakshmi, Arumugam Suresh, Muninathan Natrajan, Baskaran Kuppusamy
Department of Biochemistry, Meenakshi Medical College Hospital and Research Institute, Kanchipuram, IND.
Department of Microbiology, Meenakshi Medical College Hospital and Research Institute, Kanchipuram, IND.
Cureus. 2024 Oct 17;16(10):e71696. doi: 10.7759/cureus.71696. eCollection 2024 Oct.
Lung cancer continues to be one of the most common causes of death due to lung malignancies globally. Emerging research suggests that vitamins and trace minerals, particularly antioxidants, may play a role in cancer progression and treatment outcomes. This study conducts a comparative analysis of vitamin D, folic acid, and trace minerals (copper, zinc, and magnesium) in various stages of lung cancer patients.
A cross-sectional study was conducted with 160 lung cancer patients, categorized into four stages (Stage 1 to Stage 4). Standardized biochemical assays, such as chemiluminescent immunoassay (CLIA), enzyme-linked immunosorbent assay (ELISA), and atomic absorption spectroscopy (AAS), were used to measure the levels of vitamin D, folic acid, copper (Cu), zinc (Zn), and magnesium (Mg) in the blood. The nutrient levels were compared across stages to investigate any significant variations.
Vitamin D levels decreased significantly as lung cancer progressed, with Stage 1 showing the highest mean level (33 ng/mL) and Stage 4 the lowest (8 ng/mL). Folic acid levels fluctuated, showing a general decrease in the advanced stages, with some variations in the intermediate stages. Copper levels showed individual variability without a consistent trend across stages. Zinc levels were higher in early-stage patients and decreased as cancer progressed. Magnesium levels remained relatively stable across all stages.
This comparative analysis highlights the potential significance of monitoring vitamin D, folic acid, and trace minerals in lung cancer patients across different stages. The results suggest that these nutrients may play a role in the progression of lung cancer and could serve as biomarkers for disease staging.
肺癌仍然是全球因肺部恶性肿瘤导致死亡的最常见原因之一。新兴研究表明，维生素和微量矿物质，尤其是抗氧化剂，可能在癌症进展和治疗结果中发挥作用。本研究对肺癌患者不同阶段的维生素D、叶酸和微量矿物质（铜、锌和镁）进行了比较分析。
对160例肺癌患者进行了横断面研究，这些患者被分为四个阶段（1期至4期）。采用标准化生化检测方法，如化学发光免疫分析（CLIA）、酶联免疫吸附测定（ELISA）和原子吸收光谱法（AAS），来测量血液中维生素D、叶酸、铜（Cu）、锌（Zn）和镁（Mg）的水平。对各阶段的营养水平进行比较，以调查是否存在任何显著差异。
随着肺癌的进展，维生素D水平显著下降，1期的平均水平最高（33 ng/mL），4期最低（8 ng/mL）。叶酸水平波动，在晚期总体呈下降趋势，在中期有一些变化。铜水平表现出个体差异，各阶段没有一致的趋势。早期患者的锌水平较高，随着癌症进展而下降。镁水平在所有阶段都保持相对稳定。
这项比较分析突出了监测不同阶段肺癌患者维生素D、叶酸和微量矿物质的潜在重要性。结果表明，这些营养素可能在肺癌进展中起作用，并可作为疾病分期的生物标志物。
