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冷凝集素病、重度维生素B12缺乏与恶性贫血病例报告：致命巧合

A Case Report of Cold Agglutinin Disease, Severe B12 Deficiency, and Pernicious Anemia: A Deadly Coincidence.

作者信息

Guevara Nehemias A, Perez Esmirna, Sanchez Jorge, Rosado Flor, Sequeira Gross Harry G, Fulger Ilmana

机构信息

Internal Medicine, St. Barnabas Hospital Health System, Bronx, USA.

Internal Medicine, Department of Hematology-Oncology, St. Barnabas Hospital Health System, Bronx, USA.

出版信息

Cureus. 2023 Apr 27;15(4):e38208. doi: 10.7759/cureus.38208. eCollection 2023 Apr.

DOI:10.7759/cureus.38208
PMID:37252560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10224745/
Abstract

Anemia is the most common hematological disorder. It is commonly a manifestation of an underlying disease. Its causes are multifactorial, including but not limited to nutritional deficiencies, chronic conditions, inflammatory processes, medications, malignancy, renal dysfunction, hereditary diseases, and bone marrow disorders. We present a case of a patient exhibiting anemia related to cold agglutin disease and severe B12 deficiency secondary to pernicious anemia.

摘要

贫血是最常见的血液系统疾病。它通常是潜在疾病的一种表现。其病因是多因素的，包括但不限于营养缺乏、慢性病、炎症过程、药物、恶性肿瘤、肾功能不全、遗传性疾病和骨髓疾病。我们报告一例患者，其贫血与冷凝集素病相关，且继发于恶性贫血的严重维生素B12缺乏。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/548a/10224745/134d17abb03b/cureus-0015-00000038208-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/548a/10224745/134d17abb03b/cureus-0015-00000038208-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/548a/10224745/134d17abb03b/cureus-0015-00000038208-i01.jpg

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Hematol Rep. 2022 Jun 22;14(3):210-212. doi: 10.3390/hematolrep14030028.
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Thrombotic microangiopathy with transiently positive direct Coombs test in an adult with poststreptococcal acute glomerulonephritis: a case report.成人链球菌感染后急性肾小球肾炎合并 Coombs 试验一过性阳性的血栓性微血管病：病例报告。
BMC Nephrol. 2022 Feb 5;23(1):56. doi: 10.1186/s12882-022-02684-z.
3
Testing Practices, Interpretation, and Diagnostic Evaluation of Iron Deficiency Anemia by US Primary Care Physicians.
美国初级保健医生进行缺铁性贫血的检测实践、解读和诊断评估。
JAMA Netw Open. 2021 Oct 1;4(10):e2127827. doi: 10.1001/jamanetworkopen.2021.27827.
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Severe Vitamin B12 Deficiency Mimicking Microangiopathic Hemolytic Anemia.酷似微血管病性溶血性贫血的严重维生素B12缺乏症
J Hematol. 2021 Aug;10(4):202-205. doi: 10.14740/jh889. Epub 2021 Aug 30.
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Chronic Atrophic Gastritis Presenting as Hemolytic Anemia due to Severe Vitamin B12 Deficiency.因严重维生素B12缺乏导致溶血性贫血的慢性萎缩性胃炎
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