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与DiGeorge综合征中维生素B12缺乏和病毒感染相关的自身免疫性溶血性贫血。病例报告及文献综述。

Autoimmune hemolytic anemia associated with vitamin B12 deficiency and viral illness in DiGeorge syndrome. Case report and literature review.

作者信息

Yousaf Zohaib, Ata Fateen, Iqbal Phool, Muthanna Bassam, Khan Adeel Ahmad, Akram Jaweria, Kartha Anand

机构信息

Internal Medicine Hamad Medical Corporation Doha Qatar.

Department of Internal Medicine Hamad Medical Corporation Doha Qatar.

出版信息

Clin Case Rep. 2021 Jun 10;9(6):e04308. doi: 10.1002/ccr3.4308. eCollection 2021 Jun.

DOI:10.1002/ccr3.4308
PMID:34136241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8190680/
Abstract

Vitamin B12 plays a crucial role in cell maturation and differentiation. Its deficiency can lead to cytopenias and even hemolysis. We suggest regular monitoring and maintenance of Vit B12 levels in DiGeorge syndrome patients to prevent such triggers.

摘要

维生素B12在细胞成熟和分化过程中起着关键作用。其缺乏可导致血细胞减少，甚至溶血。我们建议定期监测和维持迪格奥尔格综合征患者的维生素B12水平，以预防此类情况的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d400/8190680/8fddc94a8216/CCR3-9-e04308-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d400/8190680/8fddc94a8216/CCR3-9-e04308-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d400/8190680/8fddc94a8216/CCR3-9-e04308-g002.jpg

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本文引用的文献

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J Allergy Clin Immunol Pract. 2019 Sep-Oct;7(7):2369-2376. doi: 10.1016/j.jaip.2019.03.014. Epub 2019 Mar 26.
2
Refractory autoimmune hemolytic anemia in a patient with DiGeorge syndrome treated successfully with plasma exchange: a case report and review of the literature.血浆置换成功治疗DiGeorge综合征患者的难治性自身免疫性溶血性贫血：病例报告及文献复习
Int J Hematol. 2014 Nov;100(5):494-7. doi: 10.1007/s12185-014-1648-1. Epub 2014 Jul 31.
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Transient effect of anti-CD20 therapy in a child with 22q11.2 deletion syndrome and severe steroid refractory cytopenias: a case report.
J Pediatr Hematol Oncol. 2013 May;35(4):311-4. doi: 10.1097/MPH.0b013e31828be602.
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DiGeorge Syndrome: a not so rare disease.DiGeorge 综合征：一种并不罕见的疾病。
Clinics (Sao Paulo). 2010;65(9):865-9. doi: 10.1590/s1807-59322010000900009.
5
Hemolysis and hyperhomocysteinemia caused by cobalamin deficiency: three case reports and review of the literature.钴胺素缺乏导致的溶血和高同型半胱氨酸血症：三例病例报告并文献复习。
J Hematol Oncol. 2008 Dec 18;1:26. doi: 10.1186/1756-8722-1-26.
6
An update on cobalamin deficiency in adults.成人维生素B12缺乏症的最新进展。
QJM. 2009 Jan;102(1):17-28. doi: 10.1093/qjmed/hcn138. Epub 2008 Nov 5.
7
A role for homocysteine increase in haemolysis of megaloblastic anaemias due to vitamin B(12) and folate deficiency: results from an in vitro experience.同型半胱氨酸升高在维生素B12和叶酸缺乏所致巨幼细胞贫血溶血中的作用：一项体外实验结果
Biochim Biophys Acta. 2004 Dec 24;1739(1):33-42. doi: 10.1016/j.bbadis.2004.08.005.
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New insights into erythropoiesis: the roles of folate, vitamin B12, and iron.红细胞生成的新见解：叶酸、维生素B12和铁的作用
Annu Rev Nutr. 2004;24:105-31. doi: 10.1146/annurev.nutr.24.012003.132306.
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