Kubota T, Nagae M, Yaoi Y, Kumasaka T, Saito M
Obstet Gynecol. 1986 Jul;68(1):80-5.
The effect of a dopamine antagonist on prolactin concentrations was studied in maternal, fetal plasma, and amniotic fluid in term gestation. Twenty-three women with normal full-term pregnancies received 10 mg metoclopramide intravenously during labor. The prolactin levels in maternal plasma increased significantly after metoclopramide. However, the prolactin levels in amniotic fluid and fetal plasma did not change significantly after administration of this drug. Although the increased values of prolactin in maternal plasma were significantly correlated with metoclopramide concentrations after metoclopramide injection, there was no correlation between these two values in amniotic fluid. The authors conclude that the prolactin-releasing system in amniotic fluid is independent of the maternal hypothalamopituitary axis.
在足月妊娠的母体、胎儿血浆及羊水中研究了多巴胺拮抗剂对催乳素浓度的影响。23例正常足月妊娠妇女在分娩期间静脉注射10毫克甲氧氯普胺。甲氧氯普胺注射后母体血浆中的催乳素水平显著升高。然而，给药后羊水和胎儿血浆中的催乳素水平没有显著变化。虽然甲氧氯普胺注射后母体血浆中催乳素升高的值与甲氧氯普胺浓度显著相关，但羊水中这两个值之间没有相关性。作者得出结论，羊水中的催乳素释放系统独立于母体下丘脑-垂体轴。
