Department of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London, 16 De Crespigny Park, London, SE5 8AF, UK.
Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, University of London, 1-19 Torrington Place, London, WC1E 7HB, UK.
BMC Genom Data. 2023 May 30;24(1):31. doi: 10.1186/s12863-023-01131-8.
Considering the co-morbidity of major psychiatric disorders and intelligence with smoking, to increase our understanding of why some people take up smoking or continue to smoke, while others stop smoking without progressing to nicotine dependence, we investigated the genetic propensities to psychiatric disorders and intelligence as determinants of smoking initiation, heaviness of smoking and smoking cessation in older adults from the general population.
Having utilised data from the English Longitudinal Study of Ageing (ELSA), our results showed that one standard deviation increase in MDD-PGS was associated with increased odds of being a moderate-heavy smoker (odds ratio [OR] = 1.11, SE = 0.04, 95%CI = 1.00-1.24, p = 0.028). There were no other significant associations between SZ-PGS, BD-PGS, or IQ-PGS and smoking initiation, heaviness of smoking and smoking cessation in older adults from the general population in the UK.
Smoking is a behaviour that does not appear to share common genetic ground with schizophrenia, bipolar disorders, and intelligence in older adults, which may suggest that it is more likely to be modifiable by smoking cessation interventions. Once started to smoke, older adults with a higher polygenic predisposition to major depressive disorders are more likely to be moderate to heavy smokers, implying that these adults may require targeted smoking cessation services.
考虑到主要精神疾病和智力与吸烟之间的共病性，为了增进我们对为什么有些人开始吸烟或继续吸烟，而另一些人则在没有发展为尼古丁依赖的情况下戒烟的理解，我们调查了精神疾病和智力的遗传倾向，作为决定普通人群中老年吸烟者开始吸烟、吸烟量和戒烟的因素。
我们利用来自英国老龄化纵向研究（ELSA）的数据，结果表明，MDD-PGS 增加一个标准差与成为中度重度吸烟者的几率增加相关（优势比 [OR] = 1.11，SE = 0.04，95%CI = 1.00-1.24，p = 0.028）。在英国普通人群中老年吸烟者开始吸烟、吸烟量和戒烟方面，SZ-PGS、BD-PGS 或 IQ-PGS 与吸烟之间没有其他显著关联。
吸烟是一种行为，似乎与精神分裂症、双相情感障碍和智力在老年人中没有共同的遗传基础，这可能表明它更容易通过戒烟干预来改变。一旦开始吸烟，具有较高多基因易患重大抑郁障碍的老年人更有可能成为中度至重度吸烟者，这意味着这些成年人可能需要有针对性的戒烟服务。
